Literature DB >> 2473306

Pharmacology of endothelin-1 in isolated vessels: effect of nicardipine, methylene blue, hemoglobin, and gossypol.

P D'Orleans-Juste1, M Finet, G de Nucci, J R Vane.   

Abstract

Sensitive bioassay tissues for porcine endothelin-1 (ET-1) were developed in a cascade superfusion system and in organ baths. Venous preparations of the rabbit and rat were more sensitive than arterial preparations. ET-1 had a different pharmacological profile than Bay K 8644 on the various preparations. Nicardipine (0.1-1 microM) abolished the responses to Bay K 8644 without affecting those induced by ET-1. Thus, ET-1 contracts venous and some arterial vessels via specific receptors or channels that differ from dihydropyridine-sensitive calcium channels. Methylene blue and hemoglobin potentiated responses to ET-1 in endothelium-denuded venous vessels, whereas gossypol had no effect.

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Year:  1989        PMID： 2473306

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  9 in total

1.  Pharmacological characterization of Ca2+ entry channels in endothelin-1-induced contraction of rat aorta using LOE 908 and SK&F 96365.

Authors:  X F Zhang; Y Iwamuro; T Enoki; M Okazawa; K Lee; T Komuro; T Minowa; Y Okamoto; H Hasegawa; H Furutani; S Miwa; T Masaki
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

2.  Effects of endothelin-1 on vascular permeability in the conscious rat: interactions with platelet-activating factor.

Authors:  J G Filep; M G Sirois; A Rousseau; A Fournier; P Sirois
Journal:  Br J Pharmacol       Date:  1991-12       Impact factor: 8.739

3.  The progestin levonorgestrel induces endothelium-independent relaxation of rabbit jugular vein via inhibition of calcium entry and protein kinase C: role of cyclic AMP.

Authors:  O Herkert; H Kuhl; R Busse; V B Schini-Kerth
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

4.  Relationship between endothelin-1 binding site densities and constrictor activities in human and animal airway smooth muscle.

Authors:  P J Henry; P J Rigby; G J Self; J M Preuss; R G Goldie
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

5.  Endothelin-1 inhibits platelet aggregation in vivo: a study with 111indium-labelled platelets.

Authors:  C Thiemermann; G R May; C P Page; J R Vane
Journal:  Br J Pharmacol       Date:  1990-02       Impact factor: 8.739

6.  Endothelin and aneurysmal subarachnoid haemorrhage: a study of subarachnoid cisternal cerebrospinal fluid.

Authors:  P Gaetani; R Rodriguez y Baena; G Grignani; G Spanu; L Pacchiarini; P Paoletti
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-01       Impact factor: 10.154

7.  Involvement of cyclo-oxygenase-generated vasodilating eicosanoid(s) in addition to nitric oxide in endothelin-1-induced endothelium-dependent vasorelaxation in guinea pig aorta.

Authors:  H Matsuda; S Beppu; F Ohmori; M Yamada; K Miyatake
Journal:  Heart Vessels       Date:  1993       Impact factor: 2.037

8.  Structure-activity studies on endothelin (16-21), the C-terminal hexapeptide of the endothelins, in the guinea-pig bronchus.

Authors:  P Rovero; R Patacchini; C A Maggi
Journal:  Br J Pharmacol       Date:  1990-09       Impact factor: 8.739

9.  Endothelin-1-induced venous contraction is maintained in DOCA-salt hypertension; studies with receptor agonists.

Authors:  Stephanie W Watts; Gregory D Fink; Carrie A Northcott; James J Galligan
Journal:  Br J Pharmacol       Date:  2002-09       Impact factor: 8.739
  9 in total

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