| Literature DB >> 2473304 |
C Van Renterghem1, P Vigne, J Barhanin, A Schmid-Alliana, C Frelin, M Lazdunski.
Abstract
The vasoconstricting action of endothelin-1 (ET-1) is partly mediated by voltage-dependent L-type Ca2+ channels. Activation of the Ca2+ channels is indirect. ET-1 action involves (i) the hydrolysis of phosphatidylinositol and the release of Ca2+ from internal stores and (ii) the opening of a nonselective cation channel in the plasma membrane. The resulting depolarization triggers the activity of L-type Ca2+ channels.Entities:
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Year: 1989 PMID： 2473304 DOI： 10.1097/00005344-198900135-00051
Source DB: PubMed Journal: J Cardiovasc Pharmacol ISSN： 0160-2446 Impact factor: 3.105