Literature DB >> 24732927

The brain-stomach connection.

C Folgueira1, L M Seoane, F F Casanueva.   

Abstract

The stomach-brain connection has been revealed to be one of the most promising targets in treating obesity. The stomach plays a key role in the homeostatic mechanism implicating stomach-brain communication regulated under neural and hormonal control. The present review explores specific topics related to gut-brain interactions focus on the stomach-brain connection through the different known systems implied in energy balance control as ghrelin, and nesfatin. Moreover, novel mechanisms for energy balance regulation involving gastric-brain communication are described including the role of the gastric intracellular mTOR/S6K1 pathway mediating the interaction among ghrelin, nesfatin and endocannabinoid gastric systems to modulate metabolism.
© 2014 S. Karger AG, Basel.

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Year:  2014        PMID： 24732927     DOI： 10.1159/000358316

Source DB:  PubMed          Journal:  Front Horm Res        ISSN： 0301-3073            Impact factor:   2.606


  7 in total

1.  Gastric Mobility and Gastrointestinal Hormones in Older Patients with Sarcopenia.

Authors:  Hsien-Hao Huang; Tse-Yao Wang; Shan-Fan Yao; Pei-Ying Lin; Julia Chia-Yu Chang; Li-Ning Peng; Liang-Kung Chen; David Hung-Tsang Yen
Journal:  Nutrients       Date:  2022-04-30       Impact factor: 6.706

2.  Epigenome-wide association study and network analysis for IgA Nephropathy from CD19+ B-cell in Chinese Population.

Authors:  Yifei Lin; Peiran Yin; Zhaozhong Zhu; Yuan Peng; Ming Li; Jun Li; Liming Liang; Xueqing Yu
Journal:  Epigenetics       Date:  2021-01-07       Impact factor: 4.528

Review 3.  Peripheral signals mediate the beneficial effects of gastric surgery in obesity.

Authors:  Silvia Barja-Fernández; Cintia Folgueira; Cecilia Castelao; Rosaura Leis; Felipe F Casanueva; Luisa M Seoane
Journal:  Gastroenterol Res Pract       Date:  2015-04-15       Impact factor: 2.260

4.  Alterations in Rat Accumbens Endocannabinoid and GABA Content during Fentanyl Treatment: The Role of Ghrelin.

Authors:  Magdalena Sustkova-Fiserova; Chrysostomos Charalambous; Tereza Havlickova; Marek Lapka; Pavel Jerabek; Nina Puskina; Kamila Syslova
Journal:  Int J Mol Sci       Date:  2017-11-22       Impact factor: 5.923

Review 5.  Drug development strategies for the treatment of obesity: how to ensure efficacy, safety, and sustainable weight loss.

Authors:  S Barja-Fernandez; R Leis; F F Casanueva; L M Seoane
Journal:  Drug Des Devel Ther       Date:  2014-12-01       Impact factor: 4.162

Review 6.  Altered gut and adipose tissue hormones in overweight and obese individuals: cause or consequence?

Authors:  M E J Lean; D Malkova
Journal:  Int J Obes (Lond)       Date:  2015-10-26       Impact factor: 5.095

7.  Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats.

Authors:  Qiang Wang; Wei Tang; Wen-Sheng Rao; Xin Song; Cheng-Xiang Shan; Wei Zhang
Journal:  World J Gastroenterol       Date:  2017-09-14       Impact factor: 5.742
  7 in total

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