Yuichiro Nishida1, Yasuki Higaki2, Naoto Taguchi3, Megumi Hara3, Kazuyo Nakamura4, Hinako Nanri3, Takeshi Imaizumi3, Tatsuhiko Sakamoto5, Mikako Horita3, Koichi Shinchi6, Keitaro Tanaka3. 1. Department of Preventive Medicine, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan. Electronic address: ynishida@cc.saga-u.ac.jp. 2. Laboratory of Exercise Physiology, Faculty of Sports and Health Science, Fukuoka University, Nanakuma 8-19-1, Fukuoka 814-0180, Japan. 3. Department of Preventive Medicine, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan. 4. St. Mary's College Faculty of Nursing, Tsubuku-honmachi 422, Kurume 830-8558, Japan. 5. Research Planning and Information Science Division, Department of Management, Fukuoka Institute of Health and Environmental Sciences, Shirakibaru 3-5-25, Onojo 816-0943, Japan. 6. Division of International Health and Nursing, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga 849-8501, Japan.
Abstract
OBJECTIVE: Studies using self-reported physical activity (PA) showed that higher PA is associated with lower circulating levels of C-reactive protein; in contrast, studies investigating associations of objective PA and other inflammatory markers are limited. We investigated cross-sectional associations of accelerometer-determined PA with circulating levels of myokine-type inflammatory cytokines in a middle-aged Japanese population. METHOD: A total of 1838 individuals (737 men and 1101 women) aged 40 to 69 years participated in the baseline survey of a population-based cohort study in Saga, Japan (2005-2007). Habitual PA was assessed by a single-axis accelerometer. Serum interleukin (IL)-4, IL-6, IL-8, IL-15, and tumor necrosis factor (TNF)-α were measured by a multiplex enzyme-linked immunosorbent assay. Associations between PA and cytokine levels were assessed by multiple regression analysis and analysis of covariance, with adjustment for potential confounders. RESULTS: Step count and PA level (PAL) were inversely associated with TNF-α and IL-15 even after adjusting for BMI. Similarly, greater PA indices were also independently associated with a lower level of inflammatory cytokine z score as an index of overall inflammation. CONCLUSION: The current results suggest that greater engagement in daily PA may be linked with reduced levels of myokine-type cytokines including IL-15, irrespective of body weight in middle-aged Japanese people.
OBJECTIVE: Studies using self-reported physical activity (PA) showed that higher PA is associated with lower circulating levels of C-reactive protein; in contrast, studies investigating associations of objective PA and other inflammatory markers are limited. We investigated cross-sectional associations of accelerometer-determined PA with circulating levels of myokine-type inflammatory cytokines in a middle-aged Japanese population. METHOD: A total of 1838 individuals (737 men and 1101 women) aged 40 to 69 years participated in the baseline survey of a population-based cohort study in Saga, Japan (2005-2007). Habitual PA was assessed by a single-axis accelerometer. Serum interleukin (IL)-4, IL-6, IL-8, IL-15, and tumor necrosis factor (TNF)-α were measured by a multiplex enzyme-linked immunosorbent assay. Associations between PA and cytokine levels were assessed by multiple regression analysis and analysis of covariance, with adjustment for potential confounders. RESULTS: Step count and PA level (PAL) were inversely associated with TNF-α and IL-15 even after adjusting for BMI. Similarly, greater PA indices were also independently associated with a lower level of inflammatory cytokine z score as an index of overall inflammation. CONCLUSION: The current results suggest that greater engagement in daily PA may be linked with reduced levels of myokine-type cytokines including IL-15, irrespective of body weight in middle-aged Japanese people.