OBJECTIVE: To investigate the effect of Lithothamnium sp (LTT) supplement, a calcium-rich alga widely used for mineral reposition, on strain-induced (orthodontic tooth movement [OTM]) and infection-induced bone resorption (periodontal disease [PD]) in mice. MATERIALS AND METHODS: Mice were divided into two bone resorption models: one with an orthodontic appliance and the other with PD induced by the oral inoculation of Aggregatibacter actinomycetencomitans (Aa). Both groups were fed a regular diet (vehicle), LTT-rich diet (LTT), or calcium-rich diet (CaCO3). Alveolar bone resorption (ABR), the number of osteoclasts, and the levels of tumor necrosis factor α (TNF-α), calcium, and vitamin D3 were evaluated. RESULTS: The number of osteoclasts was reduced in LTT and CaCO3 mice, which led to diminished OTM and infection-induced alveolar bone loss. In addition, LTT- and calcium-treated groups also presented decreased levels of TNF-α in periodontal tissues and increased levels of calcium in serum. CONCLUSIONS: These results indicate that the LTT supplement influences ABR, probably due to its calcium content, by affecting osteoclast function and local inflammatory response, thus modulating OTM and PD.
OBJECTIVE: To investigate the effect of Lithothamnium sp (LTT) supplement, a calcium-rich alga widely used for mineral reposition, on strain-induced (orthodontic tooth movement [OTM]) and infection-induced bone resorption (periodontal disease [PD]) in mice. MATERIALS AND METHODS: Mice were divided into two bone resorption models: one with an orthodontic appliance and the other with PD induced by the oral inoculation of Aggregatibacter actinomycetencomitans (Aa). Both groups were fed a regular diet (vehicle), LTT-rich diet (LTT), or calcium-rich diet (CaCO3). Alveolar bone resorption (ABR), the number of osteoclasts, and the levels of tumor necrosis factor α (TNF-α), calcium, and vitamin D3 were evaluated. RESULTS: The number of osteoclasts was reduced in LTT and CaCO3 mice, which led to diminished OTM and infection-induced alveolar bone loss. In addition, LTT- and calcium-treated groups also presented decreased levels of TNF-α in periodontal tissues and increased levels of calcium in serum. CONCLUSIONS: These results indicate that the LTT supplement influences ABR, probably due to its calcium content, by affecting osteoclast function and local inflammatory response, thus modulating OTM and PD.
Entities:
Keywords:
Bone resorption; Calcium; Orthodontic tooth movement
Authors: Cristiane M Soares; Bruna G Malagoli; Gustavo B Menezes; Vanessa Pinho; Danielle G Souza; Mauro M Teixeira; Fernão C Braga Journal: Z Naturforsch C J Biosci Date: 2012 Jul-Aug
Authors: Barbara M Rezende; Priscila T T Bernardes; Carolina B Resende; Rosa M E Arantes; Danielle G Souza; Fernão C Braga; Marina G M Castor; Mauro M Teixeira; Vanessa Pinho Journal: Mar Drugs Date: 2013-07-18 Impact factor: 5.118
Authors: Livia Nastri; Antimo Moretti; Silvia Migliaccio; Marco Paoletta; Marco Annunziata; Sara Liguori; Giuseppe Toro; Massimiliano Bianco; Gennaro Cecoro; Luigi Guida; Giovanni Iolascon Journal: Nutrients Date: 2020-01-20 Impact factor: 5.717