Literature DB >> 2472967

Structural requirement for galanin action in the pancreatic beta cell line Rin m 5F.

B Amiranoff1, A M Lorinet, N Yanaihara, M Laburthe.   

Abstract

Galanin fragments were tested for their ability to alter forskolin-stimulated cyclic AMP production and insulin release from Rin m 5F cells. Galanin and its fragments inhibited both events with the following potencies: Gal-(1-29) greater than N-AcGal-(2-29) greater than Gal-(2-29) greater than Gal-(1-15). In contrast, Gal-(3-29), Gal-(10-29) and [Ile2]Gal were inactive. [Phe2]- and [Tyr2]Gal were moderately effective. We conclude that the N-terminal portion of galanin (in particular the aromatic amino acid in position 2) is crucial for activity.

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Year:  1989        PMID： 2472967     DOI： 10.1016/0014-2999(89)90421-4

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

Review 1.  Galanin and the regulation of islet hormone secretion.

Authors:  B Ahrén; S Lindskog
Journal:  Int J Pancreatol       Date:  1992-06

2.  Synthesis of galmic: a nonpeptide galanin receptor agonist.

Authors:  Susana Conde Ceide; Laurent Trembleau; Gebhard Haberhauer; Laszlo Somogyi; Xiaoying Lu; Tamas Bartfai; Julius Rebek
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-19       Impact factor: 11.205

3.  Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide.

Authors:  W E Schmidt; H Kratzin; K Eckart; D Drevs; G Mundkowski; A Clemens; S Katsoulis; H Schäfer; B Gallwitz; W Creutzfeldt
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

Review 4.  Modes of peptide binding in G protein-coupled receptors.

Authors:  M Berthold; T Bartfai
Journal:  Neurochem Res       Date:  1997-08       Impact factor: 3.996

5.  N-terminal galanin-(1-16) fragment is an agonist at the hippocampal galanin receptor.

Authors:  G Fisone; M Berthold; K Bedecs; A Undén; T Bartfai; R Bertorelli; S Consolo; J Crawley; B Martin; S Nilsson
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

6.  Electrophysiological evidence for a hyperpolarizing, galanin (1-15)-selective receptor on hippocampal CA3 pyramidal neurons.

Authors:  Z Q Xu; X Ma; U Soomets; U Langel; T Hökfelt
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

7.  Effects of galanin, its analogues and fragments on rat isolated fundus strips.

Authors:  S Katsoulis; W E Schmidt; H Schwörer; W Creutzfeldt
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

Review 8.  A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors.

Authors:  Mark D Ericson; Carrie Haskell-Luevano
Journal:  ACS Chem Neurosci       Date:  2018-05-11       Impact factor: 4.418

9.  Galanin in an Agnathan: Precursor Identification and Localisation of Expression in the Brain of the Sea Lamprey Petromyzon marinus.

Authors:  Daniel Sobrido-Cameán; Luis Alfonso Yáñez-Guerra; Francesco Lamanna; Candela Conde-Fernández; Henrik Kaessmann; Maurice R Elphick; Ramón Anadón; María Celina Rodicio; Antón Barreiro-Iglesias
Journal:  Front Neuroanat       Date:  2019-09-13       Impact factor: 3.856
  9 in total

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