Literature DB >> 2472966

Bradykinin and substance P potentiate acetylcholine-induced bronchospasm in guinea-pig.

C Omini1, G Brunelli, A Hernandez, L Daffonchio.   

Abstract

The interaction of threshold doses of bradykinin (BK) and substance P (SP) with acetylcholine (ACh)-induced bronchospasm was investigated in anaesthetized guinea-pigs. The two peptides potentiated the ACh-induced bronchospasm, an effect which did not seem to depend on prostaglandin release. On the other hand, vagotomy abolished the capacity of BK and SP to potentiate the ACh-induced bronchospasm. The present data suggest a possible involvement of BK and SP in the genesis of airway hyperreactivity.

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Year:  1989        PMID： 2472966     DOI： 10.1016/0014-2999(89)90419-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Effect of capsaicin inhalation on methacholine responsiveness in normal subjects.

Authors:  M Fujimura; Y Kamio; T Hashimoto; T Matsuda
Journal:  Clin Auton Res       Date:  1996-02       Impact factor: 4.435

2.  Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway.

Authors:  P J Turner; J W Dear; J C Foreman
Journal:  Br J Pharmacol       Date:  2000-02       Impact factor: 8.739

3.  Role of substance P and neurokinin A in toluene diisocyanate-induced increased airway responsiveness in rabbits.

Authors:  W Marek; J J Potthast; B Marcynski; X Baur
Journal:  Lung       Date:  1996       Impact factor: 2.584

4.  Effects of bradykinin receptor antagonists on antigen-induced respiratory distress, airway hyperresponsiveness and eosinophilia in guinea-pigs.

Authors:  S G Farmer; D E Wilkins; S A Meeker; E A Seeds; C P Page
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739

5.  Potentiation by viral respiratory infection of ovalbumin-induced guinea-pig tracheal hyperresponsiveness: role for tachykinins.

Authors:  A R Ladenius; G Folkerts; H J van der Linde; F P Nijkamp
Journal:  Br J Pharmacol       Date:  1995-07       Impact factor: 8.739

Review 6.  Hyperresponsiveness in the human nasal airway: new targets for the treatment of allergic airway disease.

Authors:  P J Turner; J C Foreman
Journal:  Mediators Inflamm       Date:  1999       Impact factor: 4.711
  6 in total

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