BACKGROUND: The aim of the current study was to distinguish patients who had tremor-dominant Parkinson's disease (tPD) from those who had essential tremor with rest tremor (rET). METHODS: We combined voxel-based morphometry-derived gray matter and white matter volumes and diffusion tensor imaging-derived mean diffusivity and fractional anisotropy in a support vector machine (SVM) to evaluate 15 patients with rET and 15 patients with tPD. Dopamine transporter single-photon emission computed tomography imaging was used as ground truth. RESULTS: SVM classification of individual patients showed that no single predictor was able to fully discriminate patients with tPD from those with rET. By contrast, when all predictors were combined in a multi-modal algorithm, SVM distinguished patients with rET from those with tPD with an accuracy of 100%. CONCLUSIONS: SVM is an operator-independent and automatic technique that may help distinguish patients with tPD from those with rET at the individual level.
BACKGROUND: The aim of the current study was to distinguish patients who had tremor-dominant Parkinson's disease (tPD) from those who had essential tremor with rest tremor (rET). METHODS: We combined voxel-based morphometry-derived gray matter and white matter volumes and diffusion tensor imaging-derived mean diffusivity and fractional anisotropy in a support vector machine (SVM) to evaluate 15 patients with rET and 15 patients with tPD. Dopamine transporter single-photon emission computed tomography imaging was used as ground truth. RESULTS: SVM classification of individual patients showed that no single predictor was able to fully discriminate patients with tPD from those with rET. By contrast, when all predictors were combined in a multi-modal algorithm, SVM distinguished patients with rET from those with tPD with an accuracy of 100%. CONCLUSIONS: SVM is an operator-independent and automatic technique that may help distinguish patients with tPD from those with rET at the individual level.
Authors: Mutlu Mete; Unal Sakoglu; Jeffrey S Spence; Michael D Devous; Thomas S Harris; Bryon Adinoff Journal: BMC Bioinformatics Date: 2016-10-06 Impact factor: 3.169
Authors: Alexandra Abós; Hugo C Baggio; Bàrbara Segura; Anna I García-Díaz; Yaroslau Compta; Maria José Martí; Francesc Valldeoriola; Carme Junqué Journal: Sci Rep Date: 2017-03-28 Impact factor: 4.379