Literature DB >> 24729171

Snapshot of antidepressants at work: the structure of neurotransmitter transporter proteins.

Serena Cuboni1, Felix Hausch.   

Abstract

In the sweet spot: Cocrystal structures of engineered neurotransmitter transporters reveal the binding mode of commonly prescribed antidepressants, providing a basis for a rational drug design for this class of proteins. The picture shows the structure of the dopamine transporter of Drosophila melanogaster in complex with the antidepressant nortriptyline.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  antidepressants; membrane proteins; neurotransmitters; structure eludication; transporters

Mesh：

Substances：

Year:  2014        PMID： 24729171     DOI： 10.1002/anie.201310567

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  4 in total

Review 1.  SLC transporters as therapeutic targets: emerging opportunities.

Authors:  Lawrence Lin; Sook Wah Yee; Richard B Kim; Kathleen M Giacomini
Journal:  Nat Rev Drug Discov       Date:  2015-06-26       Impact factor: 84.694

2.  Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through Interactions with the Dopamine Transporter DAT-1.

Authors:  Osama Refai; Shaili Aggarwal; Mary Hongying Cheng; Zayna Gichi; Joseph M Salvino; Ivet Bahar; Randy D Blakely; Ole V Mortensen
Journal:  Mol Pharmacol       Date:  2021-12-14       Impact factor: 4.436

3.  Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores.

Authors:  Thomas Kirmeier; Ranganath Gopalakrishnan; Vanessa Gormanns; Anna M Werner; Serena Cuboni; Georg C Rudolf; Georg Höfner; Klaus T Wanner; Stephan A Sieber; Ulrike Schmidt; Florian Holsboer; Theo Rein; Felix Hausch
Journal:  PLoS One       Date:  2016-02-10       Impact factor: 3.240

4.  A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1).

Authors:  Andreas Jurik; Barbara Zdrazil; Marion Holy; Thomas Stockner; Harald H Sitte; Gerhard F Ecker
Journal:  J Med Chem       Date:  2015-02-26       Impact factor: 8.039
  4 in total

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