Literature DB >> 24728719

Nociceptin system as a target in sepsis?

Róisín Thomas1, Cordula Stover, David G Lambert, Jonathan P Thompson.   

Abstract

The nociceptin system comprises the nociceptin receptor (NOP) and the ligand nociceptin/orphanin FQ (N/OFQ) that binds to the receptor. The archetypal role of the system is in pain processing but the NOP receptor is also expressed on immune cells. Activation of the NOP receptor is known to modulate inflammatory responses, such as mast-cell degranulation, neutrophil rolling, vasodilation, increased vascular permeability, adhesion molecule regulation and leucocyte recruitment. As there is a loss of regulation of inflammatory responses during sepsis, the nociceptin system could be a target for therapies aimed at modulating sepsis. This review details the known effects of NOP activation on leucocytes and the vascular endothelium and discusses the most recent human and animal data on the role of the nociceptin system in sepsis.

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Year:  2014        PMID： 24728719     DOI： 10.1007/s00540-014-1818-6

Source DB:  PubMed          Journal:  J Anesth        ISSN： 0913-8668            Impact factor:   2.078


  61 in total

Review 1.  Mechanisms of organ dysfunction in critical illness: report from a Round Table Conference held in Brussels.

Authors:  M P Fink; T W Evans
Journal:  Intensive Care Med       Date:  2002-02-08       Impact factor: 17.440

Review 2.  Neutrophils in development of multiple organ failure in sepsis.

Authors:  K A Brown; S D Brain; J D Pearson; J D Edgeworth; S M Lewis; D F Treacher
Journal:  Lancet       Date:  2006-07-08       Impact factor: 79.321

3.  Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome.

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Journal:  Arch Surg       Date:  1997-12

4.  Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine.

Authors:  Zoë L S Brookes; Emily N Stedman; Remo Guerrini; Bethan K Lawton; Girolamo Calo; David G Lambert
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-08-31       Impact factor: 4.733

Review 5.  Monocyte subpopulations and their differentiation patterns during infection.

Authors:  Dalit Strauss-Ayali; Sean M Conrad; David M Mosser
Journal:  J Leukoc Biol       Date:  2007-05-02       Impact factor: 4.962

6.  Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products.

Authors:  F Colotta; F Re; N Polentarutti; S Sozzani; A Mantovani
Journal:  Blood       Date:  1992-10-15       Impact factor: 22.113

7.  Centrally administered nociceptin/orphanin FQ (N/OFQ) evokes bradycardia, hypotension, and diuresis in mice via activation of central N/OFQ peptide receptors.

Authors:  Melissa A Burmeister; Daniel R Kapusta
Journal:  J Pharmacol Exp Ther       Date:  2007-04-23       Impact factor: 4.030

8.  Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension, and diuresis are absent in N/OFQ peptide (NOP) receptor knockout mice.

Authors:  Melissa A Burmeister; Michael A Ansonoff; John E Pintar; Daniel R Kapusta
Journal:  J Pharmacol Exp Ther       Date:  2008-06-06       Impact factor: 4.030

9.  The nociceptin/orphanin FQ receptor antagonist UFP-101 reduces microvascular inflammation to lipopolysaccharide in vivo.

Authors:  Zoë L S Brookes; Emily N Stedman; Nicola J Brown; Christopher P Hebbes; Remo Guerrini; Girolamo Calo; Charles S Reilly; David G Lambert
Journal:  PLoS One       Date:  2013-09-23       Impact factor: 3.240

10.  Inflammatory mediators influence the expression of nociceptin and its receptor in human whole blood cultures.

Authors:  Lan Zhang; Frank Stuber; Ulrike M Stamer
Journal:  PLoS One       Date:  2013-09-16       Impact factor: 3.240
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  4 in total

1.  Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis.

Authors:  Divine C Nwafor; Sreeparna Chakraborty; Allison L Brichacek; Sujung Jun; Catheryne A Gambill; Wei Wang; Elizabeth B Engler-Chiurazzi; Duaa Dakhlallah; Anthony B Pinkerton; José Luis Millán; Stanley A Benkovic; Candice M Brown
Journal:  Brain Behav Immun       Date:  2019-11-25       Impact factor: 7.217

2.  Sepsis and the orexin system.

Authors:  Kazuyoshi Hirota
Journal:  J Anesth       Date:  2016-08-31       Impact factor: 2.078

Review 3.  Neuroimmune Pathophysiology in Asthma.

Authors:  Gandhi F Pavón-Romero; Nancy Haydée Serrano-Pérez; Lizbeth García-Sánchez; Fernando Ramírez-Jiménez; Luis M Terán
Journal:  Front Cell Dev Biol       Date:  2021-05-13

4.  Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats.

Authors:  Mohamed Farrag; Lacee J Laufenberg; Jennifer L Steiner; Gregory E Weller; Charles H Lang; Victor Ruiz-Velasco
Journal:  PLoS One       Date:  2015-05-27       Impact factor: 3.240
  4 in total

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