Literature DB >> 24728607

Genetic variants in loci 1p13 and 9p21 and fatal coronary heart disease in a Norwegian case-cohort study.

Mona Dverdal Jansen1, Gun Peggy Knudsen, Ronny Myhre, Gudrun Høiseth, Jørg Mørland, Øyvind Næss, Kristian Tambs, Per Magnus.   

Abstract

Single nucleotide polymorphisms (SNPs) in loci 1p13 and 9p21 have previously been found to be associated with incident coronary heart disease (CHD). This study aimed to investigate whether these SNPs show associations with fatal CHD in a population-based cohort study after adjustment for socioeconomic- and lifestyle-related CHD risk factors not commonly included in genetic association studies. Using the population-based Cohort of Norway (CONOR), a nested case-cohort study was set up and DNA from 2,953 subjects (829 cases and 2,124 non-cases) were genotyped. The association with fatal CHD was estimated for four SNPs, three from locus 1p13 and one from locus 9p21. Multivariable Cox regression was used to estimate unstratified and gender-stratified hazard ratios while adjusting for major CHD risk factors. The associations between three SNPs from locus 1p13 and non-HDL cholesterol levels were also estimated. Men homozygous for the risk alleles on rs1333049 (9p21) and rs14000 (1p13) were found to have significantly increased hazard ratios in crude and adjusted models, and the hazard ratios remained statistically significant when both genders were analyzed together. Adjustment for additional socioeconomic- and lifestyle-related CHD risk factors influenced the association estimates only slightly. No significant associations were observed between the other two SNPs in loci 1p13 (rs599839 and rs646776) and CHD mortality in either gender. Both rs599839 and rs646776 showed significant, gradual increases in non-HDL cholesterol levels with increasing number of risk alleles. This study confirms the association between 9p21 (rs1333049) and fatal CHD in a Norwegian population-based cohort. The effect was not influenced by several socioeconomic- and lifestyle-related risk factors. Our results show that 1p13 (rs14000) may also be associated with fatal CHD. SNPs at 1p13 (rs599839 and rs646776) were associated with non-HDL cholesterol levels.

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Year:  2014        PMID： 24728607     DOI： 10.1007/s11033-014-3096-7

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  32 in total

1.  Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study.

Authors:  Anika A M Vaarhorst; Yingchang Lu; Bastiaan T Heijmans; Martijn E T Dollé; Stefan Böhringer; Hein Putter; Sandra Imholz; Audrey H H Merry; Marleen M van Greevenbroek; J Wouter Jukema; Anton P M Gorgels; Piet A van den Brandt; Michael Müller; Leo J Schouten; Edith J M Feskens; Jolanda M A Boer; P Eline Slagboom
Journal:  Circ Cardiovasc Genet       Date:  2012-02-28

2.  A common variant on chromosome 9p21 affects the risk of myocardial infarction.

Authors:  Anna Helgadottir; Gudmar Thorleifsson; Andrei Manolescu; Solveig Gretarsdottir; Thorarinn Blondal; Aslaug Jonasdottir; Adalbjorg Jonasdottir; Asgeir Sigurdsson; Adam Baker; Arnar Palsson; Gisli Masson; Daniel F Gudbjartsson; Kristinn P Magnusson; Karl Andersen; Allan I Levey; Valgerdur M Backman; Sigurborg Matthiasdottir; Thorbjorg Jonsdottir; Stefan Palsson; Helga Einarsdottir; Steinunn Gunnarsdottir; Arnaldur Gylfason; Viola Vaccarino; W Craig Hooper; Muredach P Reilly; Christopher B Granger; Harland Austin; Daniel J Rader; Svati H Shah; Arshed A Quyyumi; Jeffrey R Gulcher; Gudmundur Thorgeirsson; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Science       Date:  2007-05-03       Impact factor: 47.728

3.  Invited commentary: genetic variants and individual- and societal-level risk factors.

Authors:  Steven S Coughlin
Journal:  Am J Epidemiol       Date:  2009-12-02       Impact factor: 4.897

4.  Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study.

Authors:  Jan Bressler; Aaron R Folsom; David J Couper; Kelly A Volcik; Eric Boerwinkle
Journal:  Am J Epidemiol       Date:  2009-12-02       Impact factor: 4.897

5.  Significant impact of chromosomal locus 1p13.3 on serum LDL cholesterol and on angiographically characterized coronary atherosclerosis.

Authors:  Axel Muendlein; Simone Geller-Rhomberg; Christoph H Saely; Thomas Winder; Gudrun Sonderegger; Philipp Rein; Stefan Beer; Alexander Vonbank; Heinz Drexel
Journal:  Atherosclerosis       Date:  2009-03-19       Impact factor: 5.162

6.  The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.

Authors:  Juha Karvanen; Kaisa Silander; Frank Kee; Laurence Tiret; Veikko Salomaa; Kari Kuulasmaa; Per-Gunnar Wiklund; Jarmo Virtamo; Olli Saarela; Claire Perret; Markus Perola; Leena Peltonen; Francois Cambien; Jeanette Erdmann; Nilesh J Samani; Heribert Schunkert; Alun Evans
Journal:  Genet Epidemiol       Date:  2009-04       Impact factor: 2.135

7.  Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Authors:  Heribert Schunkert; Inke R König; Sekar Kathiresan; Muredach P Reilly; Themistocles L Assimes; Hilma Holm; Michael Preuss; Alexandre F R Stewart; Maja Barbalic; Christian Gieger; Devin Absher; Zouhair Aherrahrou; Hooman Allayee; David Altshuler; Sonia S Anand; Karl Andersen; Jeffrey L Anderson; Diego Ardissino; Stephen G Ball; Anthony J Balmforth; Timothy A Barnes; Diane M Becker; Lewis C Becker; Klaus Berger; Joshua C Bis; S Matthijs Boekholdt; Eric Boerwinkle; Peter S Braund; Morris J Brown; Mary Susan Burnett; Ian Buysschaert; John F Carlquist; Li Chen; Sven Cichon; Veryan Codd; Robert W Davies; George Dedoussis; Abbas Dehghan; Serkalem Demissie; Joseph M Devaney; Patrick Diemert; Ron Do; Angela Doering; Sandra Eifert; Nour Eddine El Mokhtari; Stephen G Ellis; Roberto Elosua; James C Engert; Stephen E Epstein; Ulf de Faire; Marcus Fischer; Aaron R Folsom; Jennifer Freyer; Bruna Gigante; Domenico Girelli; Solveig Gretarsdottir; Vilmundur Gudnason; Jeffrey R Gulcher; Eran Halperin; Naomi Hammond; Stanley L Hazen; Albert Hofman; Benjamin D Horne; Thomas Illig; Carlos Iribarren; Gregory T Jones; J Wouter Jukema; Michael A Kaiser; Lee M Kaplan; John J P Kastelein; Kay-Tee Khaw; Joshua W Knowles; Genovefa Kolovou; Augustine Kong; Reijo Laaksonen; Diether Lambrechts; Karin Leander; Guillaume Lettre; Mingyao Li; Wolfgang Lieb; Christina Loley; Andrew J Lotery; Pier M Mannucci; Seraya Maouche; Nicola Martinelli; Pascal P McKeown; Christa Meisinger; Thomas Meitinger; Olle Melander; Pier Angelica Merlini; Vincent Mooser; Thomas Morgan; Thomas W Mühleisen; Joseph B Muhlestein; Thomas Münzel; Kiran Musunuru; Janja Nahrstaedt; Christopher P Nelson; Markus M Nöthen; Oliviero Olivieri; Riyaz S Patel; Chris C Patterson; Annette Peters; Flora Peyvandi; Liming Qu; Arshed A Quyyumi; Daniel J Rader; Loukianos S Rallidis; Catherine Rice; Frits R Rosendaal; Diana Rubin; Veikko Salomaa; M Lourdes Sampietro; Manj S Sandhu; Eric Schadt; Arne Schäfer; Arne Schillert; Stefan Schreiber; Jürgen Schrezenmeir; Stephen M Schwartz; David S Siscovick; Mohan Sivananthan; Suthesh Sivapalaratnam; Albert Smith; Tamara B Smith; Jaapjan D Snoep; Nicole Soranzo; John A Spertus; Klaus Stark; Kathy Stirrups; Monika Stoll; W H Wilson Tang; Stephanie Tennstedt; Gudmundur Thorgeirsson; Gudmar Thorleifsson; Maciej Tomaszewski; Andre G Uitterlinden; Andre M van Rij; Benjamin F Voight; Nick J Wareham; George A Wells; H-Erich Wichmann; Philipp S Wild; Christina Willenborg; Jaqueline C M Witteman; Benjamin J Wright; Shu Ye; Tanja Zeller; Andreas Ziegler; Francois Cambien; Alison H Goodall; L Adrienne Cupples; Thomas Quertermous; Winfried März; Christian Hengstenberg; Stefan Blankenberg; Willem H Ouwehand; Alistair S Hall; Panos Deloukas; John R Thompson; Kari Stefansson; Robert Roberts; Unnur Thorsteinsdottir; Christopher J O'Donnell; Ruth McPherson; Jeanette Erdmann; Nilesh J Samani
Journal:  Nat Genet       Date:  2011-03-06       Impact factor: 38.330

8.  Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

Authors:  Cristen J Willer; Serena Sanna; Anne U Jackson; Angelo Scuteri; Lori L Bonnycastle; Robert Clarke; Simon C Heath; Nicholas J Timpson; Samer S Najjar; Heather M Stringham; James Strait; William L Duren; Andrea Maschio; Fabio Busonero; Antonella Mulas; Giuseppe Albai; Amy J Swift; Mario A Morken; Narisu Narisu; Derrick Bennett; Sarah Parish; Haiqing Shen; Pilar Galan; Pierre Meneton; Serge Hercberg; Diana Zelenika; Wei-Min Chen; Yun Li; Laura J Scott; Paul A Scheet; Jouko Sundvall; Richard M Watanabe; Ramaiah Nagaraja; Shah Ebrahim; Debbie A Lawlor; Yoav Ben-Shlomo; George Davey-Smith; Alan R Shuldiner; Rory Collins; Richard N Bergman; Manuela Uda; Jaakko Tuomilehto; Antonio Cao; Francis S Collins; Edward Lakatta; G Mark Lathrop; Michael Boehnke; David Schlessinger; Karen L Mohlke; Gonçalo R Abecasis
Journal:  Nat Genet       Date:  2008-01-13       Impact factor: 38.330

9.  LDL-cholesterol concentrations: a genome-wide association study.

Authors:  Manjinder S Sandhu; Dawn M Waterworth; Sally L Debenham; Eleanor Wheeler; Konstantinos Papadakis; Jing Hua Zhao; Kijoung Song; Xin Yuan; Toby Johnson; Sofie Ashford; Michael Inouye; Robert Luben; Matthew Sims; David Hadley; Wendy McArdle; Philip Barter; Y Antero Kesäniemi; Robert W Mahley; Ruth McPherson; Scott M Grundy; Sheila A Bingham; Kay-Tee Khaw; Ruth J F Loos; Gérard Waeber; Inês Barroso; David P Strachan; Panagiotis Deloukas; Peter Vollenweider; Nicholas J Wareham; Vincent Mooser
Journal:  Lancet       Date:  2008-02-09       Impact factor: 79.321

10.  Cohort profile: cohort of Norway (CONOR).

Authors:  Oyvind Naess; Anne Johanne Søgaard; Egil Arnesen; Anne Cathrine Beckstrøm; Espen Bjertness; Anders Engeland; Peter F Hjort; Jostein Holmen; Per Magnus; Inger Njølstad; Grethe S Tell; Lars Vatten; Stein Emil Vollset; Geir Aamodt
Journal:  Int J Epidemiol       Date:  2007-11-04       Impact factor: 7.196
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  5 in total

1.  Association of variants in CELSR2-PSRC1-SORT1 with risk of serum lipid traits, coronary artery disease and ischemic stroke.

Authors:  Yi-Jiang Zhou; Shao-Cai Hong; Qian Yang; Rui-Xing Yin; Xiao-Li Cao; Wu-Xian Chen
Journal:  Int J Clin Exp Pathol       Date:  2015-08-01

2.  LncRNA ANRIL Expression and ANRIL Gene Polymorphisms Contribute to the Risk of Ischemic Stroke in the Chinese Han Population.

Authors:  Jialei Yang; Lian Gu; Xiaojing Guo; Jiao Huang; Zhaoxia Chen; Guifeng Huang; Yiwen Kang; Xiaoting Zhang; Jianxiong Long; Li Su
Journal:  Cell Mol Neurobiol       Date:  2018-06-07       Impact factor: 5.046

3.  Association of the genetic markers for myocardial infarction with sudden cardiac death.

Authors:  Anastasiya A Ivanova; Vladimir N Maksimov; Pavel S Orlov; Dinara E Ivanoshchuk; Sergei V Savchenko; Mikhail I Voevoda
Journal:  Indian Heart J       Date:  2016-07-30

4.  Analysis of Polymorphism rs1333049 (Located at 9P21.3) in the White Population of Western Siberia and Associations with Clinical and Biochemical Markers.

Authors:  Elena Shakhtshneider; Pavel Orlov; Sergey Semaev; Dinara Ivanoshchuk; Sofia Malyutina; Valery Gafarov; Yuliya Ragino; Mikhail Voevoda
Journal:  Biomolecules       Date:  2019-07-19

5.  New findings in the roles of Cyclin-dependent Kinase inhibitors 2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 G/C and rs4977574 A/G variants on the risk to coronary heart disease.

Authors:  Wei Yuan; Wei Zhang; Wei Zhang; Zhong-Bao Ruan; Li Zhu; Yu Liu; Yuan-Yuan Mi; Li-Feng Zhang
Journal:  Bioengineered       Date:  2020-12       Impact factor: 3.269
  5 in total

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