Literature DB >> 2472854

Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency.

J M Mienville1, S Vicini.   

Abstract

Our previous study showed antagonism of GABAA receptor-mediated whole-cell currents by pregnenolone sulfate (PS). Here, the effects of PS, picrotoxin (PTX) and pentobarbital (PB) were tested on GABA-activated single Cl- channels recorded from membrane patches of rat cortical neurons in primary cultures. PS and PTX selectively decreased the opening frequency of the channels, while PB increased mean open time and burst duration without affecting opening frequency. It is suggested that PS and PTX may antagonize GABAA receptor function through the same mechanism and/or the same binding site.

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Year:  1989        PMID： 2472854     DOI： 10.1016/0006-8993(89)90024-3

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  35 in total

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