Literature DB >> 2472845

Evidence that the hypertrophic action of clenbuterol on denervated rat muscle is not propranolol-sensitive.

C A Maltin1, S M Hay, M I Delday, P J Reeds, R M Palmer.   

Abstract

1. The effect of propranolol on the clenbuterol-induced protein anabolism in innervated and denervated soleus and plantaris muscles of the rat was studied. 2. The response to the beta-agonist, clenbuterol, in both innervated and denervated muscles, was not significantly inhibited by the beta-antagonist, propranolol. 3. The results provide further evidence to suggest that the action of clenbuterol on skeletal muscle protein accretion may not be directly mediated by beta-adrenoceptors.

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Year:  1989        PMID： 2472845      PMCID： PMC1854445          DOI： 10.1111/j.1476-5381.1989.tb11889.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  20 in total

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  10 in total

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6.  Characterization of propranolol-resistant (-)-[125I]-cyanopindolol binding sites in rat soleus muscle.

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8.  Propranolol retards revascularisation and impedes early myogenesis in regenerating skeletal muscle transplants: an autoradiographic and morphometric study in mice.

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9.  Effects of clenbuterol and propranolol on muscle mass. Evidence that clenbuterol stimulates muscle beta-adrenoceptors to induce hypertrophy.

Authors:  P A MacLennan; R H Edwards
Journal:  Biochem J       Date:  1989-12-01       Impact factor: 3.857

10.  Expression profiling of skeletal muscle following acute and chronic beta2-adrenergic stimulation: implications for hypertrophy, metabolism and circadian rhythm.

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  10 in total

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