| Literature DB >> 24727981 |
Takashi Baba1, Hiroyuki Otake1, Tetsuya Sato2, Kanako Miyabayashi1, Yurina Shishido1, Chia-Yih Wang3, Yuichi Shima1, Hiroshi Kimura4, Mikako Yagi5, Yasuhiro Ishihara6, Shinjiro Hino7, Hidesato Ogawa8, Mitsuyoshi Nakao7, Takeshi Yamazaki6, Dongchon Kang5, Yasuyuki Ohkawa9, Mikita Suyama2, Bon-Chu Chung10, Ken-Ichirou Morohashi1.
Abstract
Genetic deficiencies in transcription factors can lead to the loss of certain types of cells and tissue. The steroidogenic tissue-specific nuclear receptor Ad4BP/SF-1 (NR5A1) is one such gene, because mice in which this gene is disrupted fail to develop the adrenal gland and gonads. However, the specific role of Ad4BP/SF-1 in these biological events remains unclear. Here we use chromatin immunoprecipitation sequencing to show that nearly all genes in the glycolytic pathway are regulated by Ad4BP/SF-1. Suppression of Ad4BP/SF-1 by small interfering RNA reduces production of the energy carriers ATP and nicotinamide adenine dinucleotide phosphate, as well as lowers expression of genes involved in glucose metabolism. Together, these observations may explain tissue dysgenesis as a result of Ad4BP/SF-1 gene disruption in vivo. Considering the function of estrogen-related receptor α, the present study raises the possibility that certain types of nuclear receptors regulate sets of genes involved in metabolic pathways to generate energy carriers.Entities:
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Year: 2014 PMID： 24727981 DOI： 10.1038/ncomms4634
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919