Literature DB >> 24727902

Glycobiology: drifting toward polymer perfection.

Karen J Colley1.   

Abstract

The addition of polysialic acid to proteins and cells is emerging as a promising therapeutic strategy. Polysialyltransferases synthesize polymers of widely varying lengths not optimal for therapeutic reagents, but the development of enzyme variants using neutral genetic drift offers a new way to overcome this problem.

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Year:  2014        PMID： 24727902     DOI： 10.1038/nchembio.1506

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  9 in total

Review 1.  Use of PSA-NCAM in repair of the central nervous system.

Authors:  Abderrahman El Maarouf; Urs Rutishauser
Journal:  Adv Exp Med Biol       Date:  2010       Impact factor: 2.622

Review 2.  Improving the therapeutic efficacy of peptides and proteins: a role for polysialic acids.

Authors:  Gregory Gregoriadis; Sanjay Jain; Ioannis Papaioannou; Peter Laing
Journal:  Int J Pharm       Date:  2005-08-26       Impact factor: 5.875

Review 3.  Polysialyltransferase: a new target in metastatic cancer.

Authors:  R A Falconer; R J Errington; S D Shnyder; P J Smith; L H Patterson
Journal:  Curr Cancer Drug Targets       Date:  2012-10       Impact factor: 3.428

4.  Site-specific enzymatic polysialylation of therapeutic proteins using bacterial enzymes.

Authors:  Theresa Lindhout; Umar Iqbal; Lisa M Willis; Anne N Reid; Jianjun Li; Xin Liu; Maria Moreno; Warren W Wakarchuk
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-18       Impact factor: 11.205

Review 5.  Polysialic acid: versatile modification of NCAM, SynCAM 1 and neuropilin-2.

Authors:  Martina Mühlenhoff; Manuela Rollenhagen; Sebastian Werneburg; Rita Gerardy-Schahn; Herbert Hildebrandt
Journal:  Neurochem Res       Date:  2013-01-26       Impact factor: 3.996

6.  Engineering the product profile of a polysialyltransferase.

Authors:  Timothy G Keys; Hazel L S Fuchs; Jörg Ehrit; Jürgen Alves; Friedrich Freiberger; Rita Gerardy-Schahn
Journal:  Nat Chem Biol       Date:  2014-04-13       Impact factor: 15.040

7.  Enzymatic engineering of polysialic acid on cells in vitro and in vivo using a purified bacterial polysialyltransferase.

Authors:  Abderrahman El Maarouf; Damali Moyo-Lee Yaw; Theresa Lindhout; Damien D Pearse; Warren Wakarchuk; Urs Rutishauser
Journal:  J Biol Chem       Date:  2012-07-31       Impact factor: 5.157

8.  Chemoenzymatic synthesis of immunogenic meningococcal group C polysialic acid-tetanus Hc fragment glycoconjugates.

Authors:  Pumtiwitt C McCarthy; Rina Saksena; Dwight C Peterson; Che-Hung Lee; Yanming An; John F Cipollo; Willie F Vann
Journal:  Glycoconj J       Date:  2013-08-16       Impact factor: 2.916

Review 9.  Polysialic acid in the plasticity of the developing and adult vertebrate nervous system.

Authors:  Urs Rutishauser
Journal:  Nat Rev Neurosci       Date:  2008-01       Impact factor: 34.870
  9 in total

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