Literature DB >> 24727147

Methods to assess Drosophila heart development, function and aging.

Karen Ocorr1, Georg Vogler2, Rolf Bodmer3.   

Abstract

In recent years the Drosophila heart has become an established model for many different aspects of human cardiac disease. This model has allowed identification of disease-causing mechanisms underlying congenital heart disease and cardiomyopathies and has permitted the study of underlying genetic, metabolic and age-related contributions to heart function. In this review we discuss methods currently employed in the analysis of the Drosophila heart structure and function, such as optical methods to infer heart function and performance, electrophysiological and mechanical approaches to characterize cardiac tissue properties, and conclude with histological techniques used in the study of heart development and adult structure.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Atomic force microscopy; Cardiomyopathy; Development; Drosophila; Electrophysiology; Heart; Immunohistochemistry; KCNQ; Optical heartbeat analysis; Tinman

Mesh：

Substances：

Year:  2014        PMID： 24727147      PMCID： PMC4058868          DOI： 10.1016/j.ymeth.2014.03.031

Source DB:  PubMed          Journal:  Methods        ISSN： 1046-2023            Impact factor:   3.608


  93 in total

1.  A novel method for obtaining semi-thin cross sections of the Drosophila heart and their labeling with multiple antibodies.

Authors:  Nofar Harpaz; Talila Volk
Journal:  Methods       Date:  2011-09-22       Impact factor: 3.608

2.  Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor Hand.

Authors:  Julia Sellin; Stefanie Albrecht; Verena Kölsch; Achim Paululat
Journal:  Gene Expr Patterns       Date:  2006-02-07       Impact factor: 1.224

3.  slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.

Authors:  J M Rothberg; J R Jacobs; C S Goodman; S Artavanis-Tsakonas
Journal:  Genes Dev       Date:  1990-12       Impact factor: 11.361

4.  Control of cardiac rhythm by ORK1, a Drosophila two-pore domain potassium channel.

Authors:  Nathalie Lalevée; Bruno Monier; Sébastien Sénatore; Laurent Perrin; Michel Sémériva
Journal:  Curr Biol       Date:  2006-08-08       Impact factor: 10.834

5.  Homeotic genes autonomously specify the anteroposterior subdivision of the Drosophila dorsal vessel into aorta and heart.

Authors:  Patrick C H Lo; James B Skeath; Kathleen Gajewski; Robert A Schulz; Manfred Frasch
Journal:  Dev Biol       Date:  2002-11-15       Impact factor: 3.582

6.  Selecting a longitudinal pathway: Robo receptors specify the lateral position of axons in the Drosophila CNS.

Authors:  S Rajagopalan; V Vivancos; E Nicolas; B J Dickson
Journal:  Cell       Date:  2000-12-22       Impact factor: 41.582

7.  Slit coordinates cardiac morphogenesis in Drosophila.

Authors:  Allison MacMullin; J Roger Jacobs
Journal:  Dev Biol       Date:  2006-03-03       Impact factor: 3.582

8.  Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart.

Authors:  Sébastien Sénatore; Vatrapu Rami Reddy; Michel Sémériva; Laurent Perrin; Nathalie Lalevée
Journal:  PLoS Genet       Date:  2010-09-02       Impact factor: 5.917

9.  The gene tinman is required for specification of the heart and visceral muscles in Drosophila.

Authors:  R Bodmer
Journal:  Development       Date:  1993-07       Impact factor: 6.868

10.  The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel.

Authors:  TyAnna L Lovato; Thiennga P Nguyen; Marco R Molina; Richard M Cripps
Journal:  Development       Date:  2002-11       Impact factor: 6.868
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  40 in total

Review 1.  Gaining Insights into Diabetic Cardiomyopathy from Drosophila.

Authors:  Soda Balla Diop; Rolf Bodmer
Journal:  Trends Endocrinol Metab       Date:  2015-10-16       Impact factor: 12.015

2.  Experimental Evolution and Heart Function in Drosophila.

Authors:  Parvin Shahrestani; Molly K Burke; Ryan Birse; James N Kezos; Karen Ocorr; Laurence D Mueller; Michael R Rose; Rolf Bodmer
Journal:  Physiol Biochem Zool       Date:  2016-11-21       Impact factor: 2.247

3.  Distinct domains in the matricellular protein Lonely heart are crucial for cardiac extracellular matrix formation and heart function in Drosophila.

Authors:  Barbara Rotstein; Yanina Post; Marcel Reinhardt; Kay Lammers; Annika Buhr; Jürgen J Heinisch; Heiko Meyer; Achim Paululat
Journal:  J Biol Chem       Date:  2018-03-29       Impact factor: 5.157

4.  Age-dependent diastolic heart failure in an in vivo Drosophila model.

Authors:  Matthew P Klassen; Christian J Peters; Shiwei Zhou; Hannah H Williams; Lily Yeh Jan; Yuh Nung Jan
Journal:  Elife       Date:  2017-03-22       Impact factor: 8.140

Review 5.  Genetic manipulation of cardiac ageing.

Authors:  Leah Cannon; Rolf Bodmer
Journal:  J Physiol       Date:  2015-07-14       Impact factor: 5.182

Review 6.  Animal and in silico models for the study of sarcomeric cardiomyopathies.

Authors:  Dirk J Duncker; Jeroen Bakkers; Bianca J Brundel; Jeff Robbins; Jil C Tardiff; Lucie Carrier
Journal:  Cardiovasc Res       Date:  2015-01-18       Impact factor: 10.787

7.  PGC-1/Spargel Counteracts High-Fat-Diet-Induced Obesity and Cardiac Lipotoxicity Downstream of TOR and Brummer ATGL Lipase.

Authors:  Soda Balla Diop; Jumana Bisharat-Kernizan; Ryan Tyge Birse; Sean Oldham; Karen Ocorr; Rolf Bodmer
Journal:  Cell Rep       Date:  2015-03-05       Impact factor: 9.423

8.  Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila.

Authors:  Rachel Zarndt; Stanley M Walls; Karen Ocorr; Rolf Bodmer
Journal:  Circ Cardiovasc Genet       Date:  2017-10

9.  Model system identification of novel congenital heart disease gene candidates: focus on RPL13.

Authors:  Analyne M Schroeder; Massoud Allahyari; Georg Vogler; Maria A Missinato; Tanja Nielsen; Michael S Yu; Jeanne L Theis; Lars A Larsen; Preeya Goyal; Jill A Rosenfeld; Timothy J Nelson; Timothy M Olson; Alexandre R Colas; Paul Grossfeld; Rolf Bodmer
Journal:  Hum Mol Genet       Date:  2019-12-01       Impact factor: 6.150

Review 10.  Experimental models of Barth syndrome.

Authors:  William T Pu
Journal:  J Inherit Metab Dis       Date:  2021-08-15       Impact factor: 4.982
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