Literature DB >> 24726803

Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.

Michael P Winters1, Nalin Subasinghe2, Mark Wall2, Edward Beck2, Michael R Brandt2, Michael F A Finley2, Yi Liu2, Mary Lou Lubin2, Michael P Neeper2, Ning Qin2, Christopher M Flores2, Zhihua Sui2.   

Abstract

A novel series of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles were investigated as N-type calcium channel blockers (Cav2.2 channels), a chronic pain target. One compound was active in vivo in the rat CFA pain model.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  2,4,5,6-Tetrahydrocyclopenta[c]pyrazoles; Ca(v)2.2 blockers; N-type calcium channel; Pain; Rat CFA model

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Year:  2014        PMID： 24726803     DOI： 10.1016/j.bmcl.2014.03.063

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  1 in total

1.  The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway.

Authors:  Neidiane R Trindade; Paulo R Lopes; Lara M Naves; James O Fajemiroye; Pedro H Alves; Nathalia O Amaral; Luciano M Lião; Ana C S Rebelo; Carlos H Castro; Valdir A Braga; Ricardo Menegatti; Gustavo R Pedrino
Journal:  Front Physiol       Date:  2018-08-07       Impact factor: 4.566
  1 in total

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