Literature DB >> 24726483

Beta cell imaging - a key tool in optimized diabetes prevention and treatment.

Martin Gotthardt1, Decio L Eizirik2, Miriam Cnop3, Maarten Brom4.   

Abstract

The prevalence of diabetes is 382 million worldwide, and is expected to rise to 592 million in 2035 (http://www.idf.org/diabetesatlas); 2.5-15% of national annual healthcare budgets are related to diabetes care, potentially increasing to 40% in high-prevalence countries. Beta cell dysfunction and death are central events in diabetes pathogenesis, but the natural history of beta cell loss remains unknown. Clinical imaging of beta cells will play a pivotal role in developing strategies for optimized diabetes prevention and treatment.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  diabetes; imaging; pancreatic beta cells; pancreatic islets

Mesh：

Substances：

Year:  2014        PMID： 24726483     DOI： 10.1016/j.tem.2014.02.002

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  22 in total

Review 1.  In vivo imaging of beta cells with radiotracers: state of the art, prospects and recommendations for development and use.

Authors:  Olof Eriksson; Maren Laughlin; Maarten Brom; Pirjo Nuutila; Michael Roden; Albert Hwa; Riccardo Bonadonna; Martin Gotthardt
Journal:  Diabetologia       Date:  2016-04-19       Impact factor: 10.122

2.  In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development.

Authors:  Jia Zhao; Weijian Zong; Yiwen Zhao; Dongzhou Gou; Shenghui Liang; Jiayu Shen; Yi Wu; Xuan Zheng; Runlong Wu; Xu Wang; Fuzeng Niu; Aimin Wang; Yunfeng Zhang; Jing-Wei Xiong; Liangyi Chen; Yanmei Liu
Journal:  Elife       Date:  2019-01-29       Impact factor: 8.140

3.  Beta cell specific probing with fluorescent exendin-4 is progressively reduced in type 2 diabetic mouse models.

Authors:  Janne Lehtonen; Lauge Schäffer; Morten Grønbech Rasch; Jacob Hecksher-Sørensen; Jonas Ahnfelt-Rønne
Journal:  Islets       Date:  2015       Impact factor: 2.694

Review 4.  Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure.

Authors:  Décio L Eizirik; Lorenzo Pasquali; Miriam Cnop
Journal:  Nat Rev Endocrinol       Date:  2020-05-12       Impact factor: 43.330

Review 5.  Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes.

Authors:  Maria Lytrivi; Anne-Laure Castell; Vincent Poitout; Miriam Cnop
Journal:  J Mol Biol       Date:  2019-10-16       Impact factor: 5.469

6.  Clinical and scientific value in the pursuit of quantification of beta cells in the pancreas by PET imaging.

Authors:  Gary W Cline; Timothy J McCarthy; Richard E Carson; Roberto A Calle
Journal:  Diabetologia       Date:  2018-08-22       Impact factor: 10.460

7.  (111)In-exendin uptake in the pancreas correlates with the β-cell mass and not with the α-cell mass.

Authors:  Maarten Brom; Lieke Joosten; Cathelijne Frielink; Otto Boerman; Martin Gotthardt
Journal:  Diabetes       Date:  2014-11-19       Impact factor: 9.461

8.  Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tübingen, Germany.

Authors:  D L Bailey; B J Pichler; B Gückel; H Barthel; A J Beer; R Botnar; R Gillies; V Goh; M Gotthardt; R J Hicks; R Lanzenberger; C la Fougere; M Lentschig; S G Nekolla; T Niederdraenk; K Nikolaou; J Nuyts; D Olego; K Åhlström Riklund; A Signore; M Schäfers; V Sossi; M Suminski; P Veit-Haibach; L Umutlu; M Wissmeyer; T Beyer
Journal:  Mol Imaging Biol       Date:  2016-10       Impact factor: 3.488

9.  Whole organ and islet of Langerhans dosimetry for calculation of absorbed doses resulting from imaging with radiolabeled exendin.

Authors:  Inge van der Kroon; Wietske Woliner-van der Weg; Maarten Brom; Lieke Joosten; Cathelijne Frielink; Mark W Konijnenberg; Eric P Visser; Martin Gotthardt
Journal:  Sci Rep       Date:  2017-01-09       Impact factor: 4.379

10.  Circulating microRNA-375 as biomarker of pancreatic beta cell death and protection of beta cell mass by cytoprotective compounds.

Authors:  Imane Song; Sarah Roels; Geert A Martens; Luc Bouwens
Journal:  PLoS One       Date:  2017-10-17       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.