Literature DB >> 2472639

Functional role of human immunodeficiency virus type 1 vpu.

E F Terwilliger1, E A Cohen, Y C Lu, J G Sodroski, W A Haseltine.   

Abstract

To investigate the role of vpu in the replication and cytopathicity of human immunodeficiency virus type 1 (HIV-1), infectious proviruses were constructed that were isogenic except for the ability to produce the protein product of vpu. The vpu-encoded protein is shown to decrease the rate of syncytium formation and cell killing in infected CD4+ human T cells, to increase greatly the export of virus particles from infected cells, and to reduce the rate of accumulation of cell-associated viral proteins. The vpu protein complements in trans the defect in a vpu- HIV-1 provirus but does not affect the simian immunodeficiency virus, which lacks vpu. These observations suggest that vpu may contribute to the AIDS epidemic by increasing the transmission efficiency of the virus.

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Year:  1989        PMID： 2472639      PMCID： PMC297578          DOI： 10.1073/pnas.86.13.5163

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  31 in total

1.  Complete nucleotide sequence of the AIDS virus, HTLV-III.

Authors:  L Ratner; W Haseltine; R Patarca; K J Livak; B Starcich; S F Josephs; E R Doran; J A Rafalski; E A Whitehorn; K Baumeister
Journal:  Nature       Date:  1985 Jan 24-30       Impact factor: 49.962

2.  Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.

Authors:  J Sodroski; R Patarca; C Rosen; F Wong-Staal; W Haseltine
Journal:  Science       Date:  1985-07-05       Impact factor: 47.728

3.  Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions.

Authors:  J Sodroski; W C Goh; C Rosen; A Tartar; D Portetelle; A Burny; W Haseltine
Journal:  Science       Date:  1986-03-28       Impact factor: 47.728

4.  Cell lines that express stably env gene products from three strains of HIV-1.

Authors:  E Terwilliger; J Proulx; J Sodroski; W A Haseltine
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1988

5.  An efficient mRNA-dependent translation system from reticulocyte lysates.

Authors:  H R Pelham; R J Jackson
Journal:  Eur J Biochem       Date:  1976-08-01

6.  Human T-cell leukemia virus-associated membrane antigens: identity of the major antigens recognized after virus infection.

Authors:  T H Lee; J E Coligan; T Homma; M F McLane; N Tachibana; M Essex
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

7.  A molecular clone of HTLV-III with biological activity.

Authors:  A G Fisher; E Collalti; L Ratner; R C Gallo; F Wong-Staal
Journal:  Nature       Date:  1985 Jul 18-24       Impact factor: 49.962

8.  Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.

Authors:  J G Sodroski; C A Rosen; W A Haseltine
Journal:  Science       Date:  1984-07-27       Impact factor: 47.728

9.  Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).

Authors:  S K Arya; C Guo; S F Josephs; F Wong-Staal
Journal:  Science       Date:  1985-07-05       Impact factor: 47.728

10.  Oligonucleotide-directed mutagenesis using M13-derived vectors: an efficient and general procedure for the production of point mutations in any fragment of DNA.

Authors:  M J Zoller; M Smith
Journal:  Nucleic Acids Res       Date:  1982-10-25       Impact factor: 16.971
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  145 in total

1.  Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1.

Authors:  F M Marassi; C Ma; H Gratkowski; S K Straus; K Strebel; M Oblatt-Montal; M Montal; S J Opella
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  An in vitro rapid-turnover assay for human immunodeficiency virus type 1 replication selects for cell-to-cell spread of virus.

Authors:  S Gummuluru; C M Kinsey; M Emerman
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

3.  Expression, purification, and activities of full-length and truncated versions of the integral membrane protein Vpu from HIV-1.

Authors:  Che Ma; Francesca M Marassi; David H Jones; Suzana K Straus; Stephan Bour; Klaus Strebel; Ulrich Schubert; Myrta Oblatt-Montal; Mauricio Montal; Stanley J Opella
Journal:  Protein Sci       Date:  2002-03       Impact factor: 6.725

4.  Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity.

Authors:  T Watanabe; S Watanabe; H Ito; H Kida; Y Kawaoka
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

5.  Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release.

Authors:  H G Göttlinger; T Dorfman; J G Sodroski; W A Haseltine
Journal:  Proc Natl Acad Sci U S A       Date:  1991-04-15       Impact factor: 11.205

Review 6.  Ion channels as antivirus targets.

Authors:  Xin Liang; Zhi-Yuan Li
Journal:  Virol Sin       Date:  2010-07-28       Impact factor: 4.327

7.  Coordinate roles of Gag and RNA helicase A in promoting the annealing of formula to HIV-1 RNA.

Authors:  Li Xing; Chen Liang; Lawrence Kleiman
Journal:  J Virol       Date:  2010-11-24       Impact factor: 5.103

8.  Conformational changes induced by a single amino acid substitution in the trans-membrane domain of Vpu: implications for HIV-1 susceptibility to channel blocking drugs.

Authors:  Sang Ho Park; Stanley J Opella
Journal:  Protein Sci       Date:  2007-08-31       Impact factor: 6.725

9.  Incorporation of excess wild-type and mutant tRNA(3Lys) into human immunodeficiency virus type 1.

Authors:  Y Huang; J Mak; Q Cao; Z Li; M A Wainberg; L Kleiman
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

10.  The intracytoplasmic domain of gp41 mediates polarized budding of human immunodeficiency virus type 1 in MDCK cells.

Authors:  R Lodge; H Göttlinger; D Gabuzda; E A Cohen; G Lemay
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103
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