Lobna Gaayeb1, Claire Pinçon2, Cécile Cames3, Jean-Biram Sarr4, Modou Seck4, Anne-Marie Schacht5, Franck Remoué6, Emmanuel Hermann7, Gilles Riveau5. 1. EPLS Biomedical Research Center, Saint-Louis, Senegal; Centre for Infection and Immunity of Lille (CIIL) - U1019 Inserm, UMR8204 CNRS, Institut Pasteur de Lille, Lille, France. Electronic address: lobna.gaayeb@gmail.com. 2. Université Lille Nord de France, Lille, France. 3. UMR233 Institut de Recherche pour le Développement (IRD), Dakar, Senegal. 4. EPLS Biomedical Research Center, Saint-Louis, Senegal. 5. EPLS Biomedical Research Center, Saint-Louis, Senegal; Centre for Infection and Immunity of Lille (CIIL) - U1019 Inserm, UMR8204 CNRS, Institut Pasteur de Lille, Lille, France. 6. UMR MIVEGEC - IRD224-CNRS5290-Université de Montpellier 1 et 2, Montpellier, France. 7. EPLS Biomedical Research Center, Saint-Louis, Senegal; Centre for Infection and Immunity of Lille (CIIL) - U1019 Inserm, UMR8204 CNRS, Institut Pasteur de Lille, Lille, France; Université Lille Nord de France, Lille, France.
Abstract
BACKGROUND: While vaccines elicit a protective response in most recipients, studies suggest that environmental and nutritional factors can influence the strength of the individual response to immunization and to subsequent natural infectious challenges. METHODS: We conducted a longitudinal survey in Senegal to assess the individual response to B. pertussis, a respiratory disease against which Senegalese children are vaccinated before the age of one (Clinicaltrials.gov ID: NCT01545115). A cohort of 203 children aged 1-9 from four villages of the Senegal River Valley was followed-up for 14 months (October 2008-January 2010). During that period, four visits have been made to the villages to assess the immunological and nutritional status of these children and to determine risk factors involved in the modulation of their humoral immune response to B. pertussis toxin. RESULTS: A multivariate model has demonstrated that birth season and nutritional status appeared to modulate humoral response to pertussis toxin. Moreover, response to B. pertussis was dependent on age, village and time of visit. CONCLUSIONS: These results are consistent with the hypothesis that environmental and nutritional factors modulate children's response to pertussis following natural infection or vaccination.
BACKGROUND: While vaccines elicit a protective response in most recipients, studies suggest that environmental and nutritional factors can influence the strength of the individual response to immunization and to subsequent natural infectious challenges. METHODS: We conducted a longitudinal survey in Senegal to assess the individual response to B. pertussis, a respiratory disease against which Senegalese children are vaccinated before the age of one (Clinicaltrials.gov ID: NCT01545115). A cohort of 203 children aged 1-9 from four villages of the Senegal River Valley was followed-up for 14 months (October 2008-January 2010). During that period, four visits have been made to the villages to assess the immunological and nutritional status of these children and to determine risk factors involved in the modulation of their humoral immune response to B. pertussis toxin. RESULTS: A multivariate model has demonstrated that birth season and nutritional status appeared to modulate humoral response to pertussis toxin. Moreover, response to B. pertussis was dependent on age, village and time of visit. CONCLUSIONS: These results are consistent with the hypothesis that environmental and nutritional factors modulate children's response to pertussis following natural infection or vaccination.
Authors: Karren Xiao; Emily S Gillissie; Leanna M W Lui; Felicia Ceban; Kayla M Teopiz; Hartej Gill; Bing Cao; Roger Ho; Joshua D Rosenblat; Roger S McIntyre Journal: J Affect Disord Date: 2022-02-12 Impact factor: 4.839