| Literature DB >> 24725377 |
Abstract
High bilirubin levels are nephrotoxic. Bilirubin can cause a functional proximal tubulopathy or may precipitate into casts associated with acute tubular injury. This condition is known as bile cast nephropathy. The kidney injury is generally reversible if bilirubin levels are decreased early. We present a case wherein an alcoholic patient presented with high bilirubin levels and anuric acute kidney injury. The initial urine analysis suggested intrinsic renal disease. A kidney biopsy, performed a few days after the initiation of dialysis, demonstrated the presence of bile casts along with acute tubular injury. The patient however continued to be dialysis dependent inspite of initiating prednisolone to treat acute alcoholic hepatitis.Entities:
Keywords: Bilirubin; bile; cast; tubulopathy
Mesh:
Year: 2014 PMID: 24725377 DOI: 10.1111/hdi.12169
Source DB: PubMed Journal: Hemodial Int ISSN: 1492-7535 Impact factor: 1.812