OBJECTIVES: We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia. METHODS: Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method. RESULTS: BPA was detected in maternal blood, fetal blood and placental tissue; and actual concentrations of BPA were determined. Interestingly, significant accumulation of BPA in the placentas of women with preeclampsia compared to normotensive women has been shown. CONCLUSIONS: This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta.
OBJECTIVES: We aimed to investigate potential association between the exposure of bisphenol A (BPA) and preeclampsia. METHODS: Concentrations of BPA were assessed in 58 pregnancies including 35 normotensive and 23 preeclamptic women, using a highly sensitive gas chromatography-mass spectrometry (GC-MS) method. RESULTS:BPA was detected in maternal blood, fetal blood and placental tissue; and actual concentrations of BPA were determined. Interestingly, significant accumulation of BPA in the placentas of women with preeclampsia compared to normotensive women has been shown. CONCLUSIONS: This is the first study to highlight a significant correlation between preeclampsia and a high accumulation of BPA in the placenta.
Authors: Elise M Philips; Leonardo Trasande; Linda G Kahn; Romy Gaillard; Eric A P Steegers; Vincent W V Jaddoe Journal: Hum Reprod Date: 2019-02-01 Impact factor: 6.918
Authors: Emma M Rosen; Mg Isabel Muñoz; Thomas McElrath; David E Cantonwine; Kelly K Ferguson Journal: J Toxicol Environ Health B Crit Rev Date: 2018-12-24 Impact factor: 6.393
Authors: David E Cantonwine; John D Meeker; Kelly K Ferguson; Bhramar Mukherjee; Russ Hauser; Thomas F McElrath Journal: Environ Health Perspect Date: 2016-05-13 Impact factor: 9.031