Literature DB >> 24724012

Phospholipid micelle encapsulated gadolinium oxide nanoparticles for imaging and gene delivery.

Suraj Dixit1, Mahasweta Das2, Subbiah Alwarappan1, Nancy L Goicochea1, Mark Howell3, Subhra Mohapatra4, Shyam Mohapatra5.   

Abstract

We encapsulated gadolinium oxide (Gd2O3) nanoparticles within phospholipid micelles as a novel low cytotoxic T1-weighted MRI imaging contrast agent (MGdNPs) that can also deliver small molecules such as DNA plasmids. MGdNPs show relatively good MRI relaxivity values, negligible cytotoxicity, excellent cellular uptake and expression of DNA plasmids in vivo. Biodistribution studies in mice show that intranasal and intraperitoneal administration of MGdNPs can effectively target specific organs.

Entities:  

Year:  2013        PMID： 24724012      PMCID： PMC3979490          DOI： 10.1039/C2RA22293K

Source DB:  PubMed          Journal:  RSC Adv        ISSN： 2046-2069            Impact factor:   3.361


  23 in total

1.  Synthesis and characterization of PEGylated Gd2O3 nanoparticles for MRI contrast enhancement.

Authors:  Maria Ahrén; Linnéa Selegård; Anna Klasson; Fredrik Söderlind; Natalia Abrikossova; Caroline Skoglund; Torbjörn Bengtsson; Maria Engström; Per-Olov Käll; Kajsa Uvdal
Journal:  Langmuir       Date:  2010-04-20       Impact factor: 3.882

Review 2.  Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging.

Authors:  Willem J M Mulder; Gustav J Strijkers; Geralda A F van Tilborg; Arjan W Griffioen; Klaas Nicolay
Journal:  NMR Biomed       Date:  2006-02       Impact factor: 4.044

3.  Preparation of thiol-reactive Cy5 derivatives from commercial Cy5 succinimidyl ester.

Authors:  H J Gruber; G Kada; B Pragl; C Riener; C D Hahn; G S Harms; W Ahrer; T G Dax; K Hohenthanner; H G Knaus
Journal:  Bioconjug Chem       Date:  2000 Mar-Apr       Impact factor: 4.774

4.  Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases.

Authors:  Emilia S Olson; Tao Jiang; Todd A Aguilera; Quyen T Nguyen; Lesley G Ellies; Miriam Scadeng; Roger Y Tsien
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-16       Impact factor: 11.205

5.  Zero-length crosslinking procedure with the use of active esters.

Authors:  Z Grabarek; J Gergely
Journal:  Anal Biochem       Date:  1990-02-15       Impact factor: 3.365

Review 6.  Biochemical safety profiles of gadolinium-based extracellular contrast agents and nephrogenic systemic fibrosis.

Authors:  Hale Ersoy; Frank J Rybicki
Journal:  J Magn Reson Imaging       Date:  2007-11       Impact factor: 4.813

7.  Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging.

Authors:  Jean-Luc Bridot; Anne-Charlotte Faure; Sophie Laurent; Charlotte Rivière; Claire Billotey; Bassem Hiba; Marc Janier; Véronique Josserand; Jean-Luc Coll; Luce Vander Elst; Robert Muller; Stéphane Roux; Pascal Perriat; Olivier Tillement
Journal:  J Am Chem Soc       Date:  2007-03-31       Impact factor: 15.419

8.  Molecular imaging of alpha v beta3 integrin expression in atherosclerotic plaques with a mimetic of RGD peptide grafted to Gd-DTPA.

Authors:  Carmen Burtea; Sophie Laurent; Oltea Murariu; Dirk Rattat; Gérard Toubeau; Alfons Verbruggen; David Vansthertem; Luce Vander Elst; Robert N Muller
Journal:  Cardiovasc Res       Date:  2008-01-03       Impact factor: 10.787

9.  Paramagnetic lipid-coated silica nanoparticles with a fluorescent quantum dot core: a new contrast agent platform for multimodality imaging.

Authors:  Rolf Koole; Matti M van Schooneveld; Jan Hilhorst; Karolien Castermans; David P Cormode; Gustav J Strijkers; Celso de Mello Donegá; Daniel Vanmaekelbergh; Arjan W Griffioen; Klaas Nicolay; Zahi A Fayad; Andries Meijerink; Willem J M Mulder
Journal:  Bioconjug Chem       Date:  2008-12       Impact factor: 4.774

10.  Mesoporous Silica Nanoparticles with Co-Condensed Gadolinium Chelates for Multimodal Imaging.

Authors:  Kathryn M L Taylor-Pashow; Joseph Della Rocca; Wenbin Lin
Journal:  Nanomaterials (Basel)       Date:  2012-03-01       Impact factor: 5.076
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  2 in total

1.  Toxicity evaluation of Gd2O3@SiO2 nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo.

Authors:  Xiumei Tian; Fanwen Yang; Chuan Yang; Ye Peng; Dihu Chen; Jixiang Zhu; Fupo He; Li Li; Xiaoming Chen
Journal:  Int J Nanomedicine       Date:  2014-08-21

2.  Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage by nano-sized gadolinium oxide.

Authors:  Saud Alarifi; Huma Ali; Saad Alkahtani; Mohammed S Alessia
Journal:  Int J Nanomedicine       Date:  2017-06-21
  2 in total

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