Literature DB >> 24723198

Endoplasmic reticulum targeted chemotherapeutics: the remarkable photo-cytotoxicity of an oxovanadium(IV) vitamin-B6 complex in visible light.

Samya Banerjee1, Akanksha Dixit, Radhika N Shridharan, Anjali A Karande, Akhil R Chakravarty.   

Abstract

An oxovanadium(IV) vitamin-B6 Schiff base complex, viz. [VO(HL)(acdppz)]Cl, having (acridinyl)dipyridophenazine (acdppz) shows specific localization to endoplasmic reticulum (ER) and remarkable apoptotic photocytotoxicity in visible light (400-700 nm) in HeLa and MCF-7 cancer cells (IC50 < 0.6 μM) while being non-toxic in the dark and to MCF-10A normal cells (IC50 > 40 μM).

Entities:  

Mesh：

Substances：

Year:  2014        PMID： 24723198     DOI： 10.1039/c4cc02093f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Peroxisomes protect lymphoma cells from HDAC inhibitor-mediated apoptosis.

Authors:  Michael S Dahabieh; ZongYi Ha; Erminia Di Pietro; Jessica N Nichol; Alicia M Bolt; Christophe Goncalves; Daphné Dupéré-Richer; Filippa Pettersson; Koren K Mann; Nancy E Braverman; Sonia V Del Rincón; Wilson H Miller
Journal:  Cell Death Differ       Date:  2017-07-21       Impact factor: 15.828

2.  Enhancing the ROS generation ability of a rhodamine-decorated iridium(iii) complex by ligand regulation for endoplasmic reticulum-targeted photodynamic therapy.

Authors:  Lihua Zhou; Fangfang Wei; Jingjing Xiang; Hongfeng Li; Chunbin Li; Pengfei Zhang; Chuangjun Liu; Ping Gong; Lintao Cai; Keith Man-Chung Wong
Journal:  Chem Sci       Date:  2020-10-12       Impact factor: 9.825

Review 3.  Molecular and Cellular Mechanisms of Cytotoxic Activity of Vanadium Compounds against Cancer Cells.

Authors:  Szymon Kowalski; Dariusz Wyrzykowski; Iwona Inkielewicz-Stępniak
Journal:  Molecules       Date:  2020-04-10       Impact factor: 4.411

4.  Structurally Characterized BODIPY-Appended Oxidovanadium(IV) β-Diketonates for Mitochondria-Targeted Photocytotoxicity.

Authors:  Utso Bhattacharyya; Brijesh K Verma; Rupak Saha; Nandini Mukherjee; Md Kausar Raza; Somarupa Sahoo; Paturu Kondaiah; Akhil R Chakravarty
Journal:  ACS Omega       Date:  2020-02-24
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.