Literature DB >> 2472288

Interferons and indoleamine 2,3-dioxygenase: role in antimicrobial and antitumor effects.

J M Carlin1, Y Ozaki, G I Byrne, R R Brown, E C Borden.   

Abstract

Indoleamine 2,3-dioxygenase (IDO) is an interferon (IFN)-induced protein that initiates the metabolism of tryptophan along the kynurenine pathway. Although IDO can be induced by IFN-gamma in many cell types, only mononuclear phagocytes have been shown to be induced to decyclize tryptophan by all three IFN classes. Since tryptophan is an essential amino acid necessary for a variety of metabolic processes, depletion of available tryptophan may be an important mechanism for control of rapidly-dividing microbial pathogens and tumors. The purpose of this review is to present evidence that documents the effects of IFN-induced IDO on prokaryotic and eukaryotic pathogens, as well as on a variety of tumor cell lines.

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Year:  1989        PMID： 2472288     DOI： 10.1007/bf01990503

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  60 in total

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Journal:  Nature       Date:  1963-05-25       Impact factor: 49.962

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Journal:  Mol Biochem Parasitol       Date:  1986-09       Impact factor: 1.759

5.  Interferon-induced indoleamine 2,3-dioxygenase activity in human mononuclear phagocytes.

Authors:  J M Carlin; E C Borden; P M Sondel; G I Byrne
Journal:  J Leukoc Biol       Date:  1989-01       Impact factor: 4.962

6.  Human macrophages degrade tryptophan upon induction by interferon-gamma.

Authors:  E R Werner; G Bitterlich; D Fuchs; A Hausen; G Reibnegger; G Szabo; M P Dierich; H Wachter
Journal:  Life Sci       Date:  1987-07-20       Impact factor: 5.037

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Authors:  R Yoshida; Y Urade; M Tokuda; O Hayaishi
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

8.  Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase.

Authors:  Y Ozaki; J F Reinhard; C A Nichol
Journal:  Biochem Biophys Res Commun       Date:  1986-06-30       Impact factor: 3.575

9.  Purified human interleukin-2 enhances induction of immune interferon.

Authors:  K T Pearlstein; M A Palladino; K Welte; J Vilcek
Journal:  Cell Immunol       Date:  1983-08       Impact factor: 4.868

10.  Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

Authors:  Y Ozaki; M P Edelstein; D S Duch
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205
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  34 in total

1.  Apicomplexan parasite, Eimeria falciformis, co-opts host tryptophan catabolism for life cycle progression in mouse.

Authors:  Manuela Schmid; Maik J Lehmann; Richard Lucius; Nishith Gupta
Journal:  J Biol Chem       Date:  2012-04-25       Impact factor: 5.157

2.  Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types.

Authors:  M P Heyes; C Y Chen; E O Major; K Saito
Journal:  Biochem J       Date:  1997-09-01       Impact factor: 3.857

3.  Th1 cytokines are essential for placental immunity to Listeria monocytogenes.

Authors:  Ellen M Barber; Melissa Fazzari; Jeffrey W Pollard
Journal:  Infect Immun       Date:  2005-10       Impact factor: 3.441

4.  Systemic delivery of Salmonella typhimurium transformed with IDO shRNA enhances intratumoral vector colonization and suppresses tumor growth.

Authors:  Céline A Blache; Edwin R Manuel; Teodora I Kaltcheva; Andrea N Wong; Joshua D I Ellenhorn; Bruce R Blazar; Don J Diamond
Journal:  Cancer Res       Date:  2012-10-22       Impact factor: 12.701

5.  Indoleamine 2,3-dioxygenase: antioxidant enzyme in the human eye.

Authors:  H Z Malina; X D Martin
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-07       Impact factor: 3.117

6.  Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles.

Authors:  Masahiro Sugimoto; David T Wong; Akiyoshi Hirayama; Tomoyoshi Soga; Masaru Tomita
Journal:  Metabolomics       Date:  2009-09-10       Impact factor: 4.290

7.  Effects of gamma interferon, tumor necrosis factor alpha, and interleukin-2 on infection and proliferation of Theileria parva-infected bovine lymphoblasts and production of interferon by parasitized cells.

Authors:  J C DeMartini; C L Baldwin
Journal:  Infect Immun       Date:  1991-12       Impact factor: 3.441

8.  Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.

Authors:  Leonardo Sorci; Ian K Blaby; Irina A Rodionova; Jessica De Ingeniis; Sergey Tkachenko; Valérie de Crécy-Lagard; Andrei L Osterman
Journal:  J Bacteriol       Date:  2012-11-30       Impact factor: 3.490

9.  In vivo metabolism of tryptophan in meningiomas is mediated by indoleamine 2,3-dioxygenase 1.

Authors:  Ian M Zitron; David O Kamson; Sam Kiousis; Csaba Juhász; Sandeep Mittal
Journal:  Cancer Biol Ther       Date:  2013-01-28       Impact factor: 4.742

Review 10.  [Immunological aspects of depressive disorders].

Authors:  N Müller; M J Schwarz
Journal:  Nervenarzt       Date:  2007-11       Impact factor: 1.214
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