| Literature DB >> 24721567 |
Abstract
Pattern recognition receptors (PRR) promote pathogen eradication and shape adaptive immunity. Although evidence suggests PRRs can antagonize each other, few detailed mechanisms are known. Wevers et al. (2014) uncover a mechanism of PRR antagonism where fungal-induced Mincle signaling suppresses IL-12 transcription induced by other PRRs and thereby abates antifungal immunity.Entities:
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Year: 2014 PMID： 24721567 DOI： 10.1016/j.chom.2014.03.013
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023