| Literature DB >> 24721496 |
Ragunath Singaravelu1, Rodney S Russell2, D Lorne Tyrrell3, John Paul Pezacki4.
Abstract
It is well-established that the host microRNA (miRNA) milieu has a significant influence on the etiology of disease. In the context of viruses, such as hepatitis C virus (HCV), microRNAs have been shown to influence viral life cycles both directly, through interactions with the viral genome, and indirectly, through regulation of critical virus-associated host pathways. Several miRNA profiling studies have demonstrated that HCV infection aberrantly regulates a significant number of human miRNA. However, the biological relevance of these modulations remains poorly understood. In this review, we summarize recent research that has shed light on the pro-viral and anti-viral roles of HCV-induced changes in human miRNA expression and their significance in the development of HCV related sequelae and response to therapy. CrownEntities:
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Year: 2014 PMID： 24721496 DOI： 10.1016/j.coviro.2014.03.004
Source DB: PubMed Journal: Curr Opin Virol ISSN： 1879-6257 Impact factor: 7.090