| Literature DB >> 24721473 |
Aaron E Yancoskie1, Chandrika Sreekantaiah2, Jessy Jacob3, Amanda Rosenberg4, Morris Edelman5, Cristina R Antonescu6, John E Fantasia7.
Abstract
Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor of the jaws that is more common in the mandible than maxilla and has a female preponderance with a peak incidence in the sixth decade. It is characterized by locally aggressive behavior and has the potential to metastasize. This tumor was recently reported to have a rearrangement of the Ewing sarcoma breakpoint region 1 gene (EWS RNA-binding protein 1, EWSR1) in 5 of 8 cases tested and of the activating transcription factor 1 gene (ATF1) in 1 case tested. We report a case of CCOC in the premolar area of the mandible in a 59-year-old woman. This case demonstrated the presence of both EWSR1 and ATF1 gene rearrangements by fluorescence in situ hybridization.Entities:
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Year: 2014 PMID： 24721473 DOI： 10.1016/j.oooo.2014.02.004
Source DB: PubMed Journal: Oral Surg Oral Med Oral Pathol Oral Radiol