| Literature DB >> 24721111 |
Linda M van den Berg1, Esther M Zijlstra-Willems1, Cornelia D Richters2, Magda M W Ulrich3, Teunis B H Geijtenbeek4.
Abstract
Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs). Here we investigated the effect of beta-glucan curdlan and the role of dectin-1 expressed by keratinocytes (KCs) in wound healing. Curdlan enhanced migration, proliferation and wound closure of human KCs in a dectin-1 dependent manner, both in vitro and ex vivo. Our data suggest that curdlan induces human KC proliferation and migration and could therefore be used in creams to enhance wound healing.Entities:
Keywords: Beta-glucans; Dectin-1; Keratinocytes; Migration; Proliferation; Wound healing
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Year: 2014 PMID： 24721111 DOI： 10.1016/j.cellimm.2014.03.007
Source DB: PubMed Journal: Cell Immunol ISSN： 0008-8749 Impact factor: 4.868