OBJECTIVE: This study aimed to investigate the association between clinical and radiological markers of periodontal disease and ischemic stroke and to assess the potential influence of inflammatory response on the observed associations. METHODS: A prospective case-control study including a series of 48 cases with a minor ischemic stroke and 47 controls was conducted at the University Hospital of Dijon. Vascular risk factors, clinical dental examination (plaque index, gingival index, percentage of pockets >5 mm, percentage of bleeding on probing (BOP) sites), dental panoramic (bone loss) and biological parameters (CRP, total cholesterol, HDL, LDL, fasting glucose) were collected. Conditional regression analyses were performed to identify factors associated with ischemic stroke. RESULTS: The prevalence of hypertension, high CRP and glucose levels and overall odontological variables was higher in stroke patients. In multivariable analyses, hypertension (OR = 12.56; 95% CI = 2.29-69.96, p = 0.004), CRP levels >5 mg/L (OR = 18.54; 95% CI = 2.01-171.17, p = 0.010), BOP (OR = 1.049; 95% CI = 1.012-1.88, p = 0.009) and bone loss >20% (OR = 1.053; 95% CI = 1.017-1.091, p = 0.004) were associated with ischemic stroke. Among stroke patients, there was a non-significant trend towards higher CRP levels in patients with bone loss >20% compared with those with bone loss <20% (8.1 ± 1.27 mg/L vs 3.12 ± 3.14 mg/L, p = 0.25), whereas other biological parameters were very similar between the two groups. CONCLUSION: This case-control study demonstrates that periodontal disease, especially markers such as BOP and bone loss, is independently associated with ischemic stroke.
OBJECTIVE: This study aimed to investigate the association between clinical and radiological markers of periodontal disease and ischemic stroke and to assess the potential influence of inflammatory response on the observed associations. METHODS: A prospective case-control study including a series of 48 cases with a minor ischemic stroke and 47 controls was conducted at the University Hospital of Dijon. Vascular risk factors, clinical dental examination (plaque index, gingival index, percentage of pockets >5 mm, percentage of bleeding on probing (BOP) sites), dental panoramic (bone loss) and biological parameters (CRP, total cholesterol, HDL, LDL, fasting glucose) were collected. Conditional regression analyses were performed to identify factors associated with ischemic stroke. RESULTS: The prevalence of hypertension, high CRP and glucose levels and overall odontological variables was higher in strokepatients. In multivariable analyses, hypertension (OR = 12.56; 95% CI = 2.29-69.96, p = 0.004), CRP levels >5 mg/L (OR = 18.54; 95% CI = 2.01-171.17, p = 0.010), BOP (OR = 1.049; 95% CI = 1.012-1.88, p = 0.009) and bone loss >20% (OR = 1.053; 95% CI = 1.017-1.091, p = 0.004) were associated with ischemic stroke. Among strokepatients, there was a non-significant trend towards higher CRP levels in patients with bone loss >20% compared with those with bone loss <20% (8.1 ± 1.27 mg/L vs 3.12 ± 3.14 mg/L, p = 0.25), whereas other biological parameters were very similar between the two groups. CONCLUSION: This case-control study demonstrates that periodontal disease, especially markers such as BOP and bone loss, is independently associated with ischemic stroke.
Entities:
Keywords:
bone loss; ischemic; oral inflammation; periodontitis; risk factor; stroke
Authors: S V Kellesarian; V R Malignaggi; T V Kellesarian; A A Al-Kheraif; M M Alwageet; H Malmstrom; G E Romanos; F Javed Journal: Int J Impot Res Date: 2017-03-09 Impact factor: 2.896
Authors: Yago Leira; Juan Seoane; Miguel Blanco; Manuel Rodríguez-Yáñez; Bahi Takkouche; Juan Blanco; José Castillo Journal: Eur J Epidemiol Date: 2016-06-14 Impact factor: 8.082
Authors: Charles M Cobb; Patricia J Kelly; Karen B Williams; Shilpa Babbar; Mubashir Angolkar; Richard J Derman Journal: Int J Womens Health Date: 2017-08-08
Authors: Nathalia Carolina Fernandes Fagundes; Anna Paula Costa Ponte Sousa Carvalho Almeida; Kelly Fernanda Barbosa Vilhena; Marcela Baraúna Magno; Lucianne Cople Maia; Rafael Rodrigues Lima Journal: Vasc Health Risk Manag Date: 2019-11-06