Bei-Yun Wang1, Shi-Jin Tan. 1. Department of Geratology, Sixth People's Hospital, affiliated to Shanghai Jiaotong University , Shanghai, China .
Abstract
OBJECTIVES: To study the relationship between platelet glycoprotein IIIa gene (GP IIIa) polymorphism (Leu33Pro) and aspirin resistance in a very elderly Chinese population. METHODS: Four hundred fifty very elderly Chinese people receiving aspirin therapy were enrolled in the study. Patients who underwent arachnoid acid-induced platelet aggregation were then divided into two groups based on their resistance to aspirin: aspirin-resistant (AR) group (n=236) and aspirin-sensitive (AS) group (n=214). The Leu33Pro polymorphism of the GP IIIa gene was scanned by polymerase chain reaction-restriction fragment-length polymorphism. RESULTS: In the AR group, 224 participants had the A1/A1 genotype and 12 had the A1/A2 genotype. All patients in the AS group had the A1/A1 genotype. Thus, there was significant difference between these two groups in the genotype distribution (p<0.05). CONCLUSION: The genetic polymorphism of the GP IIIa gene was associated with AR in a very elderly Chinese population.
OBJECTIVES: To study the relationship between platelet glycoprotein IIIa gene (GP IIIa) polymorphism (Leu33Pro) and aspirin resistance in a very elderly Chinese population. METHODS: Four hundred fifty very elderly Chinese people receiving aspirin therapy were enrolled in the study. Patients who underwent arachnoid acid-induced platelet aggregation were then divided into two groups based on their resistance to aspirin: aspirin-resistant (AR) group (n=236) and aspirin-sensitive (AS) group (n=214). The Leu33Pro polymorphism of the GP IIIa gene was scanned by polymerase chain reaction-restriction fragment-length polymorphism. RESULTS: In the AR group, 224 participants had the A1/A1 genotype and 12 had the A1/A2 genotype. All patients in the AS group had the A1/A1 genotype. Thus, there was significant difference between these two groups in the genotype distribution (p<0.05). CONCLUSION: The genetic polymorphism of the GP IIIa gene was associated with AR in a very elderly Chinese population.
Authors: C Meisel; V Afshar-Kharghan; I Cascorbi; M Laule; V Stangl; S B Felix; G Baumann; J A López; I Roots; K Stangl Journal: J Am Coll Cardiol Date: 2001-10 Impact factor: 24.094
Authors: S Acikel; A Yildirir; A Aydinalp; K Demirtas; U Bal; G Kaynar; B Ozin; H Karakayali; H Muderrisoglu; M Haberal Journal: Transplant Proc Date: 2008-12 Impact factor: 1.066