Literature DB >> 24720516

Tandem N-alkylation/vinylogous aldol reaction of β,γ-alkenyl α-iminoester.

Hirotaka Tanaka1, Isao Mizota, Makoto Shimizu.   

Abstract

This report describes a highly regioselective tandem N-alkylation/vinylogous aldol reaction of β,γ-alkenyl α-iminoesters. The sulfur group improves the regioselectivity of the directed vinylogous aldol reaction, providing a new synthetic method of 3-amino-2-pyrones.

Entities:  

Year:  2014        PMID： 24720516     DOI： 10.1021/ol5007983

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  A facile approach to 2-alkoxyindolin-3-one and its application to the synthesis of N-benzyl matemone.

Authors:  Makoto Shimizu; Hayao Imazato; Isao Mizota; Yusong Zhu
Journal:  RSC Adv       Date:  2019-06-03       Impact factor: 4.036

Review 2.  Recent advances in the synthesis of 2-pyrones.

Authors:  Jong Seok Lee
Journal:  Mar Drugs       Date:  2015-03-23       Impact factor: 5.118

3.  N-Alkylation/aldol reaction of α-aldimino thioesters: a facile three-component coupling reaction.

Authors:  Makoto Shimizu; Asako Higashino; Isao Mizota; Yusong Zhu
Journal:  RSC Adv       Date:  2021-04-07       Impact factor: 3.361

4.  An umpolung reaction of α-iminothioesters possessing a cyclopropyl group.

Authors:  Makoto Shimizu; Takayoshi Morimoto; Yusuke Yanagi; Isao Mizota; Yusong Zhu
Journal:  RSC Adv       Date:  2020-03-10       Impact factor: 4.036
  4 in total

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