Literature DB >> 2472008

Persistence of abnormal chloride conductance regulation in transformed cystic fibrosis epithelia.

A M Jetten1, J R Yankaskas, M J Stutts, N J Willumsen, R C Boucher.   

Abstract

An airway epithelial cell line (CF/T43) was developed by infecting cultured airway epithelial cells from patients with cystic fibrosis (CF) with the pZIPneoSV(X)1/SV40T retrovirus and selecting for G418 resistance and ion transport properties. The distinctive chloride secretory phenotypes of the CF cell line CF/T43 and a normal cell line (NL/T4) were not perturbed by SV40T-induced cell transformation. Epithelial cell lines generated from CF cells with the SV40T gene can be used to test candidate CF genes and to evaluate the molecular mechanisms responsible for the CF phenotype.

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Year:  1989        PMID： 2472008     DOI： 10.1126/science.2472008

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  21 in total

1.  An improved cell culture model based on 2/4/A1 cell monolayers for studies of intestinal drug transport: characterization of transport routes.

Authors:  Staffan Tavelin; Jan Taipalensuu; Finn Hallböök; Kati-Sisko Vellonen; Vanessa Moore; Per Artursson
Journal:  Pharm Res       Date:  2003-03       Impact factor: 4.200

2.  A transformed human epithelial cell line that retains tight junctions post crisis.

Authors:  A L Cozens; M J Yezzi; M Yamaya; D Steiger; J A Wagner; S S Garber; L Chin; E M Simon; G R Cutting; P Gardner
Journal:  In Vitro Cell Dev Biol       Date:  1992 Nov-Dec

Review 3.  Basic aspects of cystic fibrosis.

Authors:  J J Wine
Journal:  Clin Rev Allergy       Date:  1991 Spring-Summer

4.  Characterization of a Ca(2+)-dependent anion channel from sheep tracheal epithelium incorporated into planar bilayers.

Authors:  E W Alton; S D Manning; P J Schlatter; D M Geddes; A J Williams
Journal:  J Physiol       Date:  1991-11       Impact factor: 5.182

5.  Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer.

Authors:  A Mastrangeli; C Danel; M A Rosenfeld; L Stratford-Perricaudet; M Perricaudet; A Pavirani; J P Lecocq; R G Crystal
Journal:  J Clin Invest       Date:  1993-01       Impact factor: 14.808

6.  Terminal glycosylation of cystic fibrosis airway epithelial cells.

Authors:  A D Rhim; V A Kothari; P J Park; A E Mulberg; M C Glick; T F Scanlin
Journal:  Glycoconj J       Date:  2000-06       Impact factor: 2.916

7.  Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels.

Authors:  Beate Illek; Rosalie Maurisse; Logan Wahler; Karl Kunzelmann; Horst Fischer; Dieter C Gruenert
Journal:  Cell Physiol Biochem       Date:  2008-07-25

8.  Inhibition of epithelial chloride channels by cytosol.

Authors:  K Kunzelmann; M Tilmann; C P Hansen; R Greger
Journal:  Pflugers Arch       Date:  1991-06       Impact factor: 3.657

9.  Epithelial cell specific properties and genetic complementation in a delta F508 cystic fibrosis nasal polyp cell line.

Authors:  K Kunzelmann; D C Lei; K Eng; L C Escobar; T Koslowsky; D C Gruenert
Journal:  In Vitro Cell Dev Biol Anim       Date:  1995-09       Impact factor: 2.416

10.  Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells.

Authors:  A L Cozens; M J Yezzi; L Chin; E M Simon; W E Finkbeiner; J A Wagner; D C Gruenert
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205
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