Literature DB >> 24719978

Recent advances in clinical applications of circulating cell-free DNA integrity.

Jiajia Yu, Guohao Gu, Shaoqing Ju.   

Abstract

Circulating DNA is an emerging biomarker in various types of cancer. It is generally believed that DNA released from apoptotic cells is uniformly truncated to small DNA fragments with 185-200 base pair (bp), whereas DNA produced by malignant cells varies in size (most of these are longer DNA fragments). Recently, the application of circulating DNA integrity indexes, represented by the ratio of the longer DNA fragments concentration to the shorter ones, has been reported in different cancers. This review will summarize the recently reported assays for detection of the circulating cell-free DNA (ccf-DNA) integrity and their clinical utility.

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Year:  2014        PMID： 24719978     DOI： 10.1309/lmkkox6ujzqgw0ea

Source DB:  PubMed          Journal:  Lab Med        ISSN： 0007-5027


  12 in total

1.  Plasma DNA integrity index as a potential molecular diagnostic marker for breast cancer.

Authors:  Azza M Kamel; Salwa Teama; Amal Fawzy; Mervat El Deftar
Journal:  Tumour Biol       Date:  2015-12-18

2.  Detection of Taenia solium DNA in the Urine of Neurocysticercosis Patients.

Authors:  Luz Toribio; Miryam Romano; Alan L Scott; Isidro Gonzales; Herbert Saavedra; Hector H Garcia; Clive Shiff
Journal:  Am J Trop Med Hyg       Date:  2019-02       Impact factor: 2.345

Review 3.  Current challenges for detection of circulating tumor cells and cell-free circulating nucleic acids, and their characterization in non-small cell lung carcinoma patients. What is the best blood substrate for personalized medicine?

Authors:  Marius Ilie; Véronique Hofman; Elodie Long; Olivier Bordone; Eric Selva; Kevin Washetine; Charles Hugo Marquette; Paul Hofman
Journal:  Ann Transl Med       Date:  2014-11

4.  Diagnosis of Pneumocystis jirovecii pneumonia with serum cell-free DNA in non-HIV-infected immunocompromised patients.

Authors:  Dong Wang; Yang Hu; Ting Li; Heng-Mo Rong; Zhao-Hui Tong
Journal:  Oncotarget       Date:  2017-05-20

Review 5.  Colorectal Cancer Blood-Based Biomarkers.

Authors:  Nina Hauptman; Damjan Glavač
Journal:  Gastroenterol Res Pract       Date:  2017-09-25       Impact factor: 2.260

6.  Comparison of paired cerebrospinal fluid and serum cell-free mitochondrial and nuclear DNA with copy number and fragment length.

Authors:  Aolong Chen; Jun Li; Lei Wang; Qin Huang; Jiajin Zhu; Shumeng Wen; Jianxin Lyu; Wenhe Wu
Journal:  J Clin Lab Anal       Date:  2020-02-13       Impact factor: 2.352

7.  Transrenal DNA-based diagnosis of Strongyloides stercoralis (Grassi, 1879) infection: Bayesian latent class modeling of test accuracy.

Authors:  Alejandro J Krolewiecki; Artemis Koukounari; Miryam Romano; Reynaldo N Caro; Alan L Scott; Pedro Fleitas; Ruben Cimino; Clive J Shiff
Journal:  PLoS Negl Trop Dis       Date:  2018-06-01

8.  Plasma Circulating Cell-free DNA Integrity as a Promising Biomarker for Diagnosis and Surveillance in Patients with Hepatocellular Carcinoma.

Authors:  Ao Huang; Xin Zhang; Shao-Lai Zhou; Ya Cao; Xiao-Wu Huang; Jia Fan; Xin-Rong Yang; Jian Zhou
Journal:  J Cancer       Date:  2016-08-12       Impact factor: 4.207

9.  Cell-free circulating DNA integrity is an independent predictor of impending breast cancer recurrence.

Authors:  Barbara Burwinkel; Harald Surowy; Jie Cheng; Katarina Cuk; Jörg Heil; Michael Golatta; Sarah Schott; Christof Sohn; Andreas Schneeweiss
Journal:  Oncotarget       Date:  2017-04-24

10.  Alu methylation serves as a biomarker for non-invasive diagnosis of glioma.

Authors:  Jian Chen; Wei Huan; Hao Zuo; Longxiang Zhao; Chuanjun Huang; Xiaojiang Liu; Shiqiang Hou; Jing Qi; Wei Shi
Journal:  Oncotarget       Date:  2016-05-03
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