BACKGROUND/AIMS: The aims of the current retrospective cohort study were to compare OS of the primary resection (R-g) and the non-resection group (NR-g) after 2005. METHODOLOGY: Ninety-five patients with stage IV colorectal cancer with unresectable distant metastases were divided into 2 groups; R-g; 37 and NR-g; 58. RESULTS: The only significant difference in clinical factors between the 2 was R0 resection rate (p = 0.007). The MST in R-g was superior to that in NR-g, 30.7 vs. 21.9 months (p = 0.031). After excluding the patients that underwent R0 resection, there was no difference in OS between the 2; however, the MST was 28.6 months in R-g and 17.1 months in NR-g. CONCLUSIONS: The advantage of resection of the primary is still unclear and a well-designed randomized Phase III study is expected. However, the current results suggest that resection of the primary lesion before intensive chemotherapy had some benefit for prognosis.
BACKGROUND/AIMS: The aims of the current retrospective cohort study were to compare OS of the primary resection (R-g) and the non-resection group (NR-g) after 2005. METHODOLOGY: Ninety-five patients with stage IV colorectal cancer with unresectable distant metastases were divided into 2 groups; R-g; 37 and NR-g; 58. RESULTS: The only significant difference in clinical factors between the 2 was R0 resection rate (p = 0.007). The MST in R-g was superior to that in NR-g, 30.7 vs. 21.9 months (p = 0.031). After excluding the patients that underwent R0 resection, there was no difference in OS between the 2; however, the MST was 28.6 months in R-g and 17.1 months in NR-g. CONCLUSIONS: The advantage of resection of the primary is still unclear and a well-designed randomized Phase III study is expected. However, the current results suggest that resection of the primary lesion before intensive chemotherapy had some benefit for prognosis.
Authors: Constantinos Simillis; Eliana Kalakouti; Thalia Afxentiou; Christos Kontovounisios; Jason J Smith; David Cunningham; Michel Adamina; Paris P Tekkis Journal: World J Surg Date: 2019-07 Impact factor: 3.352
Authors: Narimantas E Samalavicius; Audrius Dulskas; Edita Baltruskeviciene; Giedre Smailyte; Marija Skuciene; Rasa Mikelenaite; Rasa Venslovaite; Eduardas Aleknavicius; Almantas Samalavicius; Raimundas Lunevicius Journal: Wideochir Inne Tech Maloinwazyjne Date: 2016-12-31 Impact factor: 1.195