Literature DB >> 24719787

Cross-tissue comparisons of leptin and adiponectin: DNA methylation profiles.

Andrée-Anne Houde1, Cécilia Légaré1, Frédéric-Simon Hould2, Stéfane Lebel2, Picard Marceau2, André Tchernof3, Marie-Claude Vohl4, Marie-France Hivert5, Luigi Bouchard1.   

Abstract

DNA methylation has been mostly studied in circulating blood cells. Although being readily accessible, metabolically active tissues such as adipose tissue would be more informative for the study of metabolic disorders. However, whether or not the blood DNA methylation profile correlates with that of adipose tissue remains unknown. In this study, DNA methylation patterns of variation at LEP and ADIPOQ gene loci were similar between individual CpGs across the different tissues. We also report that DNA methylation levels at biologically relevant CpGs are correlated between blood, subcutaneous, and visceral adipose tissue, and that these nearby CpGs are associated with LEP and ADIPOQ gene expression in adipose tissues. These results will be highly relevant for future epigenetic studies in metabolic disorders.

Entities:  

Keywords:  blood; epigenetics; subcutaneous adipose tissue; visceral adipose tissue

Year:  2014        PMID： 24719787      PMCID： PMC3979878          DOI： 10.4161/adip.28308

Source DB:  PubMed          Journal:  Adipocyte        ISSN： 2162-3945            Impact factor:   4.534


  42 in total

1.  Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter.

Authors:  Matilde Marchi; Simonetta Lisi; Michele Curcio; Serena Barbuti; Paolo Piaggi; Giovanni Ceccarini; Monica Nannipieri; Marco Anselmino; Claudio Di Salvo; Paolo Vitti; Aldo Pinchera; Ferruccio Santini; Margherita Maffei
Journal:  Epigenetics       Date:  2011-10-01       Impact factor: 4.528

2.  Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.

Authors:  C T Montague; J B Prins; L Sanders; J E Digby; S O'Rahilly
Journal:  Diabetes       Date:  1997-03       Impact factor: 9.461

3.  Adaptations of placental and cord blood ABCA1 DNA methylation profile to maternal metabolic status.

Authors:  Andrée-Anne Houde; Simon-Pierre Guay; Véronique Desgagné; Marie-France Hivert; Jean-Patrice Baillargeon; Julie St-Pierre; Patrice Perron; Daniel Gaudet; Diane Brisson; Luigi Bouchard
Journal:  Epigenetics       Date:  2013-10-10       Impact factor: 4.528

4.  Deoxyribonucleic acid methylation and gene expression of PPARGC1A in human muscle is influenced by high-fat overfeeding in a birth-weight-dependent manner.

Authors:  Charlotte Brøns; Stine Jacobsen; Emma Nilsson; Tina Rönn; Christine B Jensen; Heidi Storgaard; Pernille Poulsen; Leif Groop; Charlotte Ling; Arne Astrup; Allan Vaag
Journal:  J Clin Endocrinol Metab       Date:  2010-04-21       Impact factor: 5.958

Review 5.  Adipocytokines and the metabolic complications of obesity.

Authors:  Neda Rasouli; Philip A Kern
Journal:  J Clin Endocrinol Metab       Date:  2008-11       Impact factor: 5.958

6.  DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific.

Authors:  Elmar W Tobi; L H Lumey; Rudolf P Talens; Dennis Kremer; Hein Putter; Aryeh D Stein; P Eline Slagboom; Bastiaan T Heijmans
Journal:  Hum Mol Genet       Date:  2009-08-04       Impact factor: 6.150

7.  Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors.

Authors:  Corina Lesseur; David A Armstrong; Alison G Paquette; Devin C Koestler; James F Padbury; Carmen J Marsit
Journal:  Mol Cell Endocrinol       Date:  2013-07-30       Impact factor: 4.102

8.  A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin.

Authors:  J Hoffstedt; P Eriksson; S Mottagui-Tabar; P Arner
Journal:  Horm Metab Res       Date:  2002-07       Impact factor: 2.936

9.  Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Authors:  Jordana T Bell; Pei-Chien Tsai; Tsun-Po Yang; Ruth Pidsley; James Nisbet; Daniel Glass; Massimo Mangino; Guangju Zhai; Feng Zhang; Ana Valdes; So-Youn Shin; Emma L Dempster; Robin M Murray; Elin Grundberg; Asa K Hedman; Alexandra Nica; Kerrin S Small; Emmanouil T Dermitzakis; Mark I McCarthy; Jonathan Mill; Tim D Spector; Panos Deloukas
Journal:  PLoS Genet       Date:  2012-04-19       Impact factor: 5.917

10.  Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration.

Authors:  Luigi Bouchard; Marie-France Hivert; Simon-Pierre Guay; Julie St-Pierre; Patrice Perron; Diane Brisson
Journal:  Diabetes       Date:  2012-03-06       Impact factor: 9.461
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  14 in total

1.  Placental lipoprotein lipase DNA methylation alterations are associated with gestational diabetes and body composition at 5 years of age.

Authors:  Valérie Gagné-Ouellet; Andrée-Anne Houde; Simon-Pierre Guay; Patrice Perron; Daniel Gaudet; Renée Guérin; Baillargeon Jean-Patrice; Marie-France Hivert; Diane Brisson; Luigi Bouchard
Journal:  Epigenetics       Date:  2017-05-09       Impact factor: 4.528

2.  CPT1A methylation is associated with plasma adiponectin.

Authors:  S Aslibekyan; A N Do; H Xu; S Li; M R Irvin; D Zhi; H K Tiwari; D M Absher; A R Shuldiner; T Zhang; W Chen; K Tanner; C Hong; B D Mitchell; G Berenson; D K Arnett
Journal:  Nutr Metab Cardiovasc Dis       Date:  2016-11-23       Impact factor: 4.222

3.  Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats.

Authors:  Annaliese K Beery; Lisa M McEwen; Julia L MacIsaac; Darlene D Francis; Michael S Kobor
Journal:  Horm Behav       Date:  2015-06-27       Impact factor: 3.587

Review 4.  Genetic Determination of Serum Levels of Diabetes-Associated Adipokines.

Authors:  Dorit Schleinitz
Journal:  Rev Diabet Stud       Date:  2016-01-28

5.  DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS.

Authors:  Bárbara Echiburú; Fermín Milagro; Nicolás Crisosto; Francisco Pérez-Bravo; Cristian Flores; Ana Arpón; Francisca Salas-Pérez; Sergio E Recabarren; Teresa Sir-Petermann; Manuel Maliqueo
Journal:  Epigenetics       Date:  2020-04-20       Impact factor: 4.528

Review 6.  Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond.

Authors:  Zhiyong Cheng; Louise Zheng; Fabio A Almeida
Journal:  J Nutr Biochem       Date:  2017-10-23       Impact factor: 6.048

7.  Methylation analysis in fatty-acid-related genes reveals their plasticity associated with conjugated linoleic acid and calcium supplementation in adult mice.

Authors:  Alice Chaplin; Andreu Palou; Francisca Serra
Journal:  Eur J Nutr       Date:  2015-12-23       Impact factor: 5.614

8.  Circulating adiponectin and risk of endometrial cancer.

Authors:  Qiaoli Zheng; Haijian Wu; Jiang Cao
Journal:  PLoS One       Date:  2015-06-01       Impact factor: 3.240

9.  Regional distribution of body fat in relation to DNA methylation within the LPL, ADIPOQ and PPARγ promoters in subcutaneous adipose tissue.

Authors:  D Drogan; H Boeing; J Janke; B Schmitt; Y Zhou; J Walter; T Pischon; S Tierling
Journal:  Nutr Diabetes       Date:  2015-07-06       Impact factor: 5.097

Review 10.  Developmental programming: State-of-the-science and future directions-Summary from a Pennington Biomedical symposium.

Authors:  Elizabeth F Sutton; L Anne Gilmore; David B Dunger; Bas T Heijmans; Marie-France Hivert; Charlotte Ling; J Alfredo Martinez; Susan E Ozanne; Rebecca A Simmons; Moshe Szyf; Robert A Waterland; Leanne M Redman; Eric Ravussin
Journal:  Obesity (Silver Spring)       Date:  2016-04-01       Impact factor: 5.002
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