Jin Yong Hong1, Jungsu S Oh, Injoo Lee, Mun Kyung Sunwoo, Jee Hyun Ham, Ji E Lee, Young H Sohn, Jae Seung Kim, Phil Hyu Lee. 1. From the Department of Neurology (J.Y.H.), Yonsei University Wonju College of Medicine, Wonju; the Department of Nuclear Medicine (J.S.O., I.L., J.S.K.), Asan Medical Center, University of Ulsan College of Medicine, Seoul; and the Department of Neurology and Brain Research Institute (J.Y.H., M.K.S., J.H.H., J.E.L., Y.H.S., P.H.L.) and Severance Biomedical Science Institute (P.H.L.), Yonsei University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE: To investigate whether the magnitude of presynaptic dopamine depletion is a risk factor for the development of levodopa-induced dyskinesia (LID) in Parkinson disease (PD) by quantitatively analyzing (18)F-FP-CIT PET data. METHODS: This retrospective cohort study enrolled a total of 127 drug-naive de novo patients with PD who completed (18)F-FP-CIT PET scanning at their initial evaluation. The patients visited our outpatient clinic every 3-6 months and had been followed for a minimum of 2 years since beginning dopaminergic medication. The predictive power of the quantitatively analyzed (18)F-FP-CIT uptake of striatal subregions and other clinical factors for the development of LID was evaluated using Cox proportional hazard models. RESULTS: During a mean follow-up period of 3.4 years, 35 patients with PD (27.6%) developed LID. Patients with LID showed less dopamine transporter (DAT) activity in the putamen than did those without LID. Multivariate Cox proportional hazard models revealed that the DAT uptakes of the anterior putamen (hazard ratio [HR] 0.530; p = 0.032), posterior putamen (HR 0.302; p = 0.024), and whole putamen (HR 0.386; p = 0.022) were significant predictors of the development of LID, whereas DAT activities in the caudate and ventral striatum were not significantly correlated with the development of LID. In addition, younger age at onset of PD and higher dose of levodopa were also significant predictors of the development of LID. CONCLUSIONS: The present results provide convincing evidence that presynaptic dopaminergic denervation in PD plays a crucial role in the development of LID.
OBJECTIVE: To investigate whether the magnitude of presynaptic dopamine depletion is a risk factor for the development of levodopa-induced dyskinesia (LID) in Parkinson disease (PD) by quantitatively analyzing (18)F-FP-CIT PET data. METHODS: This retrospective cohort study enrolled a total of 127 drug-naive de novo patients with PD who completed (18)F-FP-CIT PET scanning at their initial evaluation. The patients visited our outpatient clinic every 3-6 months and had been followed for a minimum of 2 years since beginning dopaminergic medication. The predictive power of the quantitatively analyzed (18)F-FP-CIT uptake of striatal subregions and other clinical factors for the development of LID was evaluated using Cox proportional hazard models. RESULTS: During a mean follow-up period of 3.4 years, 35 patients with PD (27.6%) developed LID. Patients with LID showed less dopamine transporter (DAT) activity in the putamen than did those without LID. Multivariate Cox proportional hazard models revealed that the DAT uptakes of the anterior putamen (hazard ratio [HR] 0.530; p = 0.032), posterior putamen (HR 0.302; p = 0.024), and whole putamen (HR 0.386; p = 0.022) were significant predictors of the development of LID, whereas DAT activities in the caudate and ventral striatum were not significantly correlated with the development of LID. In addition, younger age at onset of PD and higher dose of levodopa were also significant predictors of the development of LID. CONCLUSIONS: The present results provide convincing evidence that presynaptic dopaminergic denervation in PD plays a crucial role in the development of LID.
Authors: Seok Jong Chung; Han Soo Yoo; Hye Sun Lee; Hyo Eun Jeong; Soo-Jong Kim; Jungsu S Oh; Jae Seung Kim; Young H Sohn; Phil Hyu Lee Journal: CNS Drugs Date: 2018-10 Impact factor: 5.749
Authors: Han Soo Yoo; Seok Jong Chung; Su Jin Chung; Hyojeong Moon; Jung Su Oh; Jae Seung Kim; Jin Yong Hong; Byoung Seok Ye; Young Ho Sohn; Phil Hyu Lee Journal: Eur J Nucl Med Mol Imaging Date: 2017-10-26 Impact factor: 9.236