| Literature DB >> 24718872 |
Sabina Sieri1, Paolo Chiodini1, Claudia Agnoli1, Valeria Pala1, Franco Berrino1, Antonia Trichopoulou1, Vassiliki Benetou1, Effie Vasilopoulou1, María-José Sánchez1, Maria-Dolores Chirlaque1, Pilar Amiano1, J Ramón Quirós1, Eva Ardanaz1, Genevieve Buckland1, Giovanna Masala1, Salvatore Panico1, Sara Grioni1, Carlotta Sacerdote1, Rosario Tumino1, Marie-Christine Boutron-Ruault1, Françoise Clavel-Chapelon1, Guy Fagherazzi1, Petra H M Peeters1, Carla H van Gils1, H Bas Bueno-de-Mesquita1, Henk J van Kranen1, Timothy J Key1, Ruth C Travis1, Kay Tee Khaw1, Nicholas J Wareham1, Rudolf Kaaks1, Annekatrin Lukanova1, Heiner Boeing1, Madlen Schütze1, Emily Sonestedt1, Elisabeth Wirfält1, Malin Sund1, Anne Andersson1, Veronique Chajes1, Sabina Rinaldi1, Isabelle Romieu1, Elisabete Weiderpass1, Guri Skeie1, Engeset Dagrun1, Anne Tjønneland1, Jytte Halkjær1, Kim Overvard1, Melissa A Merritt1, David Cox1, Elio Riboli1, Vittorio Krogh1.
Abstract
We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.Entities:
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Year: 2014 PMID： 24718872 DOI： 10.1093/jnci/dju068
Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506