Literature DB >> 2471781

Characterization of antigenic variants of tick-borne encephalitis virus selected with neutralizing monoclonal antibodies.

H Holzmann1, C W Mandl, F Guirakhoo, F X Heinz, C Kunz.   

Abstract

Antigenic variants of tick-borne encephalitis virus were selected by the use of six neutralizing monoclonal antibodies (MAbs), each defining a different epitope of the envelope glycoprotein E. These variants were characterized with respect to antigenic changes by analysing the binding of each of 18 precisely mapped MAbs in ELISA and haemagglutination inhibition tests. The results yielded information about interrelations between epitopes exceeding that obtained previously from competitive binding studies. In addition, variants were tested for their specific haemagglutination activities, which revealed a significant reduction of this functional activity in one of the variants.

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Year:  1989        PMID： 2471781     DOI： 10.1099/0022-1317-70-1-219

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  10 in total

1.  A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.

Authors:  Jennifer R Keeffe; Koen K A Van Rompay; Priscilla C Olsen; Qiao Wang; Anna Gazumyan; Stephanie A Azzopardi; Dennis Schaefer-Babajew; Yu E Lee; Jackson B Stuart; Anil Singapuri; Jennifer Watanabe; Jodie Usachenko; Amir Ardeshir; Mohsan Saeed; Marianna Agudelo; Thomas Eisenreich; Stylianos Bournazos; Thiago Y Oliveira; Charles M Rice; Lark L Coffey; Margaret R MacDonald; Pamela J Bjorkman; Michel C Nussenzweig; Davide F Robbiani
Journal:  Cell Rep       Date:  2018-11-06       Impact factor: 9.423

2.  Tick-borne encephalitis virus envelope protein E-specific monoclonal antibodies for the study of low pH-induced conformational changes and immature virions.

Authors:  H Holzmann; K Stiasny; H York; F Dorner; C Kunz; F X Heinz
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

3.  A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model.

Authors:  H Holzmann; F X Heinz; C W Mandl; F Guirakhoo; C Kunz
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

4.  A multiplex ELISA-based protein array for screening diagnostic antigens and diagnosis of Flaviviridae infection.

Authors:  D Wang; Y Zheng; X Kang; X Zhang; H Hao; W Chen; L Liu; X Li; L Li; Q Yuan; F Chen; Y Yang; Y Jiang; H Jiang
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2015-03-22       Impact factor: 3.267

5.  Neuroblastoma cell-adapted yellow fever 17D virus: characterization of a viral variant associated with persistent infection and decreased virus spread.

Authors:  Leonsia A Vlaycheva; Thomas J Chambers
Journal:  J Virol       Date:  2002-06       Impact factor: 5.103

6.  Expression of cloned envelope protein genes from the flavivirus tick-borne encephalitis virus in mammalian cells and random mutagenesis by PCR.

Authors:  S L Allison; C W Mandl; C Kunz; F X Heinz
Journal:  Virus Genes       Date:  1994-07       Impact factor: 2.332

7.  Aluminum hydroxide influences not only the extent but also the fine specificity and functional activity of antibody responses to tick-borne encephalitis virus in mice.

Authors:  Juergen Zlatkovic; Georgios Tsouchnikas; Johanna Jarmer; Christian Koessl; Karin Stiasny; Franz X Heinz
Journal:  J Virol       Date:  2013-09-04       Impact factor: 5.103

8.  West Nile virus: characterization and diagnostic applications of monoclonal antibodies.

Authors:  Davide Lelli; Ana Moreno; Emiliana Brocchi; Enrica Sozzi; Lorenzo Capucci; Elena Canelli; Ilaria Barbieri; Herve Zeller; Paolo Cordioli
Journal:  Virol J       Date:  2012-04-13       Impact factor: 4.099

9.  Analysis of specific IgG titers against tick-borne encephalitis in patients with primary antibody deficiency under immunoglobulin substitution therapy: impact of plasma donor origin.

Authors:  Sigune Goldacker; Torsten Witte; Daniela Huzly; Michael Schlesier; Hans-Hartmut Peter; Klaus Warnatz
Journal:  Front Immunol       Date:  2015-01-05       Impact factor: 7.561

Review 10.  Structures and mechanisms in flavivirus fusion.

Authors:  F X Heinz; S L Allison
Journal:  Adv Virus Res       Date:  2000       Impact factor: 9.937
  10 in total

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