Literature DB >> 24717009

Iron dysregulation in Huntington's disease.

Michelle Muller1, Blair R Leavitt.   

Abstract

Huntington's disease (HD) is one of many neurodegenerative diseases with reported alterations in brain iron homeostasis that may contribute to neuropathogenesis. Iron accumulation in the specific brain areas of neurodegeneration in HD has been proposed based on observations in post-mortem tissue and magnetic resonance imaging studies. Altered magnetic resonance imaging signal within specific brain regions undergoing neurodegeneration has been consistently reported and interpreted as altered levels of brain iron. Biochemical studies using various techniques to measure iron species in human samples, mouse tissue, or in vitro has generated equivocal data to support such an association. Whether elevated brain iron occurs in HD, plays a significant contributing role in HD pathogenesis, or is a secondary effect remains currently unclear.
© 2014 International Society for Neurochemistry.

Entities:  

Keywords:  Huntington's disease; huntingtin; iron; magnetic resonance imaging; microglia; neurodegeneration

Mesh：

Substances：

Year:  2014        PMID： 24717009     DOI： 10.1111/jnc.12739

Source DB:  PubMed          Journal:  J Neurochem        ISSN： 0022-3042            Impact factor:   5.372


  35 in total

1.  Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease.

Authors:  J M G van Bergen; J Hua; P G Unschuld; I A L Lim; C K Jones; R L Margolis; C A Ross; P C M van Zijl; X Li
Journal:  AJNR Am J Neuroradiol       Date:  2015-12-17       Impact factor: 3.825

Review 2.  Iron and Neurodegeneration: Is Ferritinophagy the Link?

Authors:  Giorgio Biasiotto; Diego Di Lorenzo; Silvana Archetti; Isabella Zanella
Journal:  Mol Neurobiol       Date:  2015-10-14       Impact factor: 5.590

3.  Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment.

Authors:  Pan Chen; Melissa Totten; Ziyan Zhang; Hana Bucinca; Keith Erikson; Abel Santamaría; Aaron B Bowman; Michael Aschner
Journal:  Expert Rev Neurother       Date:  2019-02-21       Impact factor: 4.618

4.  Echogenicity of basal ganglia structures in different Huntington's disease phenotypes.

Authors:  Carsten Saft; Rainer Hoffmann; Katrin Strassburger-Krogias; Thomas Lücke; Saskia H Meves; Gisa Ellrichmann; Christos Krogias
Journal:  J Neural Transm (Vienna)       Date:  2014-12-13       Impact factor: 3.575

5.  Substantia nigra hyperechogenicity in hypokinetic Huntington's disease patients.

Authors:  Johann Lambeck; Wolf-Dirk Niesen; Matthias Reinhard; Reinhard Matthias; Cornelius Weiller; Matthias Dose; Dose Matthias; Birgit Zucker; Zucker Birgit
Journal:  J Neurol       Date:  2015-01-09       Impact factor: 4.849

6.  Altered brain iron content and deposition rate in Huntington's disease as indicated by quantitative susceptibility MRI.

Authors:  Lin Chen; Jun Hua; Christopher A Ross; Shuhui Cai; Peter C M van Zijl; Xu Li
Journal:  J Neurosci Res       Date:  2018-11-29       Impact factor: 4.164

Review 7.  Ferroptosis: Death by Lipid Peroxidation.

Authors:  Wan Seok Yang; Brent R Stockwell
Journal:  Trends Cell Biol       Date:  2015-12-02       Impact factor: 20.808

Review 8.  The Emerging Roles of Ferroptosis in Huntington's Disease.

Authors:  Yajing Mi; Xingchun Gao; Hao Xu; Yuanyuan Cui; Yuelin Zhang; Xingchun Gou
Journal:  Neuromolecular Med       Date:  2019-01-02       Impact factor: 3.843

Review 9.  Role of iron in neurodegenerative diseases.

Authors:  Kai Li; Heinz Reichmann
Journal:  J Neural Transm (Vienna)       Date:  2016-01-21       Impact factor: 3.575

Review 10.  Brain Iron Metabolism Dysfunction in Parkinson's Disease.

Authors:  Hong Jiang; Jun Wang; Jack Rogers; Junxia Xie
Journal:  Mol Neurobiol       Date:  2016-04-02       Impact factor: 5.590
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