OBJECTIVE: Knowledge about levels of toxic and non-toxic elements in amniotic fluid is limited. The aims of this study were: (1) to measure levels of trace elements Cu, Fe, Zn, B, Sr and Co in amniotic fluid and maternal serum during second trimester of pregnancy; and (2) to determine what correlations exists between elements levels in amniotic fluid and maternal serum. METHODS: The levels of, iron, copper, zinc, cobalt, strontium and boron were measured in blood and amniotic fluid during genetic amniocentesis using inductively coupled plasma mass spectrometry (ICP-MS). RESULTS: Concentrations of the elements: Fe, Cu, Zn, Co, Sr and B in amniotic fluid were significantly lower than in maternal blood. For iron, zinc, cobalt, strontium and boron there was a linear correlation between levels in amniotic fluid and maternal serum. CONCLUSIONS: The concentration of trace elements in amniotic fluid was found to be lower than maternal serum and linearly correlated to its level.
OBJECTIVE: Knowledge about levels of toxic and non-toxic elements in amniotic fluid is limited. The aims of this study were: (1) to measure levels of trace elements Cu, Fe, Zn, B, Sr and Co in amniotic fluid and maternal serum during second trimester of pregnancy; and (2) to determine what correlations exists between elements levels in amniotic fluid and maternal serum. METHODS: The levels of, iron, copper, zinc, cobalt, strontium and boron were measured in blood and amniotic fluid during genetic amniocentesis using inductively coupled plasma mass spectrometry (ICP-MS). RESULTS: Concentrations of the elements: Fe, Cu, Zn, Co, Sr and B in amniotic fluid were significantly lower than in maternal blood. For iron, zinc, cobalt, strontium and boron there was a linear correlation between levels in amniotic fluid and maternal serum. CONCLUSIONS: The concentration of trace elements in amniotic fluid was found to be lower than maternal serum and linearly correlated to its level.
Entities:
Keywords:
Amniotic fluid; inductively coupled plasma mass spectroscopy; trace elements
Authors: Allison L Fisher; Veena Sangkhae; Pietro Presicce; Claire A Chougnet; Alan H Jobe; Suhas G Kallapur; Sammy Tabbah; Catalin S Buhimschi; Irina A Buhimschi; Tomas Ganz; Elizabeta Nemeth Journal: JCI Insight Date: 2020-02-27