Shahrzad Aghaamoo1, Azra Azmoodeh2, Fardin Yousefshahi3, Katayon Berjis2, Farahnazsadat Ahmady4, Kamran Qods5, Majid Mirmohammadkhani6. 1. Department of Gynecology, Semnan University of Medical Sciences, Semnan, Iran. 2. Department of Reproduction & Infertility, Tehran University of Medical Sciences, Tehran, Iran. 3. Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran. 4. Department of Gynecology, Tehran University of Medical Sciences, Tehran, Iran. 5. Departmemt of Surgery, Semnan University of Medical Sciences, Semnan, Iran. 6. Research Center for Social Determinants of Health, Semnan University of Medical Sciences, Semnan, Iran.
Abstract
OBJECTIVE: Because of high psychological burden and considerable costs of in-vitro fertilization, it is greatly important to identify all factors that may influence its results. In this study, general anesthesia and spinal analgesia used for oocyte retrieval were compared in terms of success in treating infertility among couples who had undergone in-vitro fertilization at an infertility center in Tehran, Iran. METHODS: This cohort study that was based on analysis of patient records at Mirza Kochak Khan Hospital, Tehran University of Medical Sciences, in 2008-2009. In this study, the status of chemical pregnancy among those who experienced general anesthesia or spinal anesthesia for in-vitro fertilization for the first time were compared, and the possible effects of clinical and laboratory factors using logistic regression models were considered. RESULTS: Considering the number of transferred embryos, underlying cause of infertility and fetus grade, it was found that practicing spinal anesthesia is significantly related to increased chance of chemical pregnancy (adjusted Odds Ratio=2.07; 95% CI: 1.02,4.20; p=0.043). CONCLUSION: According to analysis of recorded data in an infertility treatment center in Iran, it is recommended to use spinal anesthesia instead of general anesthesia for oocyte retrieval to achieve successful in-vitro fertilization outcome. This can be studied and investigated further via a proper multicentric study in the country.
OBJECTIVE: Because of high psychological burden and considerable costs of in-vitro fertilization, it is greatly important to identify all factors that may influence its results. In this study, general anesthesia and spinal analgesia used for oocyte retrieval were compared in terms of success in treating infertility among couples who had undergone in-vitro fertilization at an infertility center in Tehran, Iran. METHODS: This cohort study that was based on analysis of patient records at Mirza Kochak Khan Hospital, Tehran University of Medical Sciences, in 2008-2009. In this study, the status of chemical pregnancy among those who experienced general anesthesia or spinal anesthesia for in-vitro fertilization for the first time were compared, and the possible effects of clinical and laboratory factors using logistic regression models were considered. RESULTS: Considering the number of transferred embryos, underlying cause of infertility and fetus grade, it was found that practicing spinal anesthesia is significantly related to increased chance of chemical pregnancy (adjusted Odds Ratio=2.07; 95% CI: 1.02,4.20; p=0.043). CONCLUSION: According to analysis of recorded data in an infertility treatment center in Iran, it is recommended to use spinal anesthesia instead of general anesthesia for oocyte retrieval to achieve successful in-vitro fertilization outcome. This can be studied and investigated further via a proper multicentric study in the country.
Entities:
Keywords:
Cohort; General anesthesia; In-vitro fertilization; Iran; Spinal analgesia