Literature DB >> 2471492

Relative induction of molecular forms of cytochrome P-450 in gamma-hexachlorocyclohexane exposed rat liver microsomes.

A Kumar1, P P Dwivedi.   

Abstract

The effect of gamma-hexachlorocyclohexane (HCH), (25 mg/kg body weight, i.p., administered for 4 consecutive days) on the induction of types of cytochrome P-450 in rat liver microsomes was studied. Induced proteins were characterized by "Western" blot analysis, using anticytochrome P-450 antibodies. It was observed that HCH is a "mixed-type" inducer and mediates induction of cytochrome P-450 b/e forms by several fold and of cytochrome P-450 c and d forms by nearly three fold.

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Year:  1988        PMID： 2471492     DOI： 10.1007/bf00288355

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  19 in total

1.  Induction of liver growth by xenobiotic compounds and other stimuli.

Authors:  R Schulte-Hermann
Journal:  CRC Crit Rev Toxicol       Date:  1974-09

2.  Low speed preparation of microsomes: a comparative study.

Authors:  R C Baker; L B Coons; E Hodgson
Journal:  Chem Biol Interact       Date:  1973-05       Impact factor: 5.192

3.  Biodegradation of chemicals of environmental concern.

Authors:  M Alexander
Journal:  Science       Date:  1981-01-09       Impact factor: 47.728

4.  Characteristics of a microsomal cytochrome P-448-mediated reaction. Ethoxyresorufin O-de-ethylation.

Authors:  M D Burke; R A Prough; R T Mayer
Journal:  Drug Metab Dispos       Date:  1977 Jan-Feb       Impact factor: 3.922

5.  Effects of lindane treatment on drug metabolizing enzymes and liver weight of CF1 mice in which it evoked hepatomas and in non-susceptible rodents.

Authors:  F Oesch; T Friedberg; M Herbst; W Paul; N Wilhelm; P Bentley
Journal:  Chem Biol Interact       Date:  1982-05       Impact factor: 5.192

6.  Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species.

Authors:  A Kumar; C Raphael; M Adesnik
Journal:  J Biol Chem       Date:  1983-09-25       Impact factor: 5.157

7.  Studies on the synthesis of cytochrome P-450 and cytochrome P-448 in rat liver.

Authors:  A Kumar; G Padmanaban
Journal:  J Biol Chem       Date:  1980-01-25       Impact factor: 5.157

8.  Induction of cytochrome P-450 isozymes by hexachlorobenzene in rats and aromatic hydrocarbon (Ah)-responsive mice.

Authors:  P Linko; H N Yeowell; T A Gasiewicz; J A Goldstein
Journal:  J Biochem Toxicol       Date:  1986-06

9.  Anaerobic dechlorination and degradation of hexachlorocyclohexane isomers by anaerobic and facultative anaerobic bacteria.

Authors:  G Jagnow; K Haider; P C Ellwardt
Journal:  Arch Microbiol       Date:  1977-12-15       Impact factor: 2.552

10.  Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.

Authors:  P E Thomas; L M Reik; D E Ryan; W Levin
Journal:  J Biol Chem       Date:  1983-04-10       Impact factor: 5.157
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  2 in total

1.  Interaction of lindane and carbaryl on hepatic microsomal enzymes in rats.

Authors:  J Krechniak; B Englot; K Wrześniowska; E Hać
Journal:  Bull Environ Contam Toxicol       Date:  1994-06       Impact factor: 2.151

2.  Pesticides induced oxidative stress in thymocytes.

Authors:  Selen Olgun; Hara P Misra
Journal:  Mol Cell Biochem       Date:  2006-05-23       Impact factor: 3.396
  2 in total

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