OBJECTIVES: To explore gallbladder cancer (GBC), the second leading cause of cancer-related death in women in Chile. METHODS: Analysis of macroscopic and microscopic variables, morphometry, and survival in 1,366 patients with GBC. RESULTS: Patients comprised 1,138 women and 228 men; diagnoses included 213 (15.6%) cases of mucosal carcinoma, 132 (9.7%) cases of muscular carcinoma, 316 (23.1%) cases of subserosal carcinoma, 382 (28.0%) cases of serosal carcinoma, and 323 (23.6%) cases beyond the serosa. Women older than 55 years with a gallbladder length greater than 9.5 cm had a five-times-greater relative risk of cancer. Those with a gallbladder wall thickness less than 7 mm had a better 5-year survival rate than those with a gallbladder wall thickness greater than 10 mm (P = .0001). Patients who had cholesterolosis of the gallbladder had 9.2 times less probability of having cancer. The infiltration level of the gallbladder wall was the most important independent prognostic factor (P < .001), followed by differentiation and lymphatic involvement (P < .001 and P = .05, respectively). Vascular infiltration had a mortality rate of 100%. CONCLUSIONS: Morphologic features are strongly associated with the prognosis of GBC and must be taken into consideration when supplementary treatment is recommended.
OBJECTIVES: To explore gallbladder cancer (GBC), the second leading cause of cancer-related death in women in Chile. METHODS: Analysis of macroscopic and microscopic variables, morphometry, and survival in 1,366 patients with GBC. RESULTS:Patients comprised 1,138 women and 228 men; diagnoses included 213 (15.6%) cases of mucosal carcinoma, 132 (9.7%) cases of muscular carcinoma, 316 (23.1%) cases of subserosal carcinoma, 382 (28.0%) cases of serosal carcinoma, and 323 (23.6%) cases beyond the serosa. Women older than 55 years with a gallbladder length greater than 9.5 cm had a five-times-greater relative risk of cancer. Those with a gallbladder wall thickness less than 7 mm had a better 5-year survival rate than those with a gallbladder wall thickness greater than 10 mm (P = .0001). Patients who had cholesterolosis of the gallbladder had 9.2 times less probability of having cancer. The infiltration level of the gallbladder wall was the most important independent prognostic factor (P < .001), followed by differentiation and lymphatic involvement (P < .001 and P = .05, respectively). Vascular infiltration had a mortality rate of 100%. CONCLUSIONS: Morphologic features are strongly associated with the prognosis of GBC and must be taken into consideration when supplementary treatment is recommended.
Authors: Paula Fluxá; Daniel Rojas-Sepúlveda; María Alejandra Gleisner; Andrés Tittarelli; Pablo Villegas; Loreto Tapia; María Teresa Rivera; Mercedes Natalia López; Felipe Catán; Mario Uribe; Flavio Salazar-Onfray Journal: BMC Cancer Date: 2018-03-02 Impact factor: 4.430
Authors: Eun Kyung Hong; Kun Kuk Kim; Jung Nam Lee; Woon Kee Lee; Min Chung; Yeon Suk Kim; Yeon Ho Park Journal: Korean J Hepatobiliary Pancreat Surg Date: 2014-11-30
Authors: Vívian D'Afonseca; Ariel D Arencibia; Alex Echeverría-Vega; Leslie Cerpa; Juan P Cayún; Nelson M Varela; Marcela Salazar; Luis A Quiñones Journal: Cancer Inform Date: 2020-05-25