Literature DB >> 2471354

N-AgIB of poliovirus type 1: a discontinuous epitope formed by two loops of VP1 comprising residues 96-104 and 141-152.

K Wiegers1, H Uhlig, R Dernick.   

Abstract

Analysis of resistant mutants to neutralizing monoclonal antibodies revealed a discontinuous neutralization epitope on VP1 of poliovirus type 1, Mahoney. The epitope has the unique property of being also part of a sequential epitope within neutralization antigenic site I (N-AgI). It is formed by residues in the loop 96-104 connecting the B and C strand and in the loop 141-152 connecting the D and E strand of VP1. Because of strong analogy to neutralization immunogen IB (NImIB) of human rhinovirus 14 (HRV-14) we have called this site N-AgIB of poliovirus type 1.

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Year:  1989        PMID： 2471354     DOI： 10.1016/0042-6822(89)90452-2

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  17 in total

1.  Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis.

Authors:  K Wiegers; R Dernick
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

2.  Generation of hybrid genes and proteins by vaccinia virus-mediated recombination: application to human immunodeficiency virus type 1 env.

Authors:  L Gritz; A Destree; N Cormier; E Day; V Stallard; T Caiazzo; G Mazzara; D Panicali
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

3.  Differential recruitment of B and T cells in coxsackievirus B4-induced pancreatitis is influenced by a capsid protein.

Authors:  A I Ramsingh; W T Lee; D N Collins; L E Armstrong
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

4.  Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

Authors:  K J Wiegers; K Wetz; R Dernick
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

5.  Structural factors modulate the activity of antigenic poliovirus sequences expressed on hybrid hepatitis B surface antigen particles.

Authors:  F Delpeyroux; E Van Wezel; B Blondel; R Crainic
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

6.  Construction of a poliovirus type 1/type 2 antigenic hybrid by manipulation of neutralization antigenic site II.

Authors:  A D Murdin; E Wimmer
Journal:  J Virol       Date:  1989-12       Impact factor: 5.103

7.  Dynamics of Evolution of Poliovirus Neutralizing Antigenic Sites and Other Capsid Functional Domains during a Large and Prolonged Outbreak.

Authors:  Jing Shaw; Jaume Jorba; Kun Zhao; Jane Iber; Qi Chen; Festus Adu; Adekunle Adeniji; David Bukbuk; Marycelin Baba; Elizabeth Henderson; Naomi Dybdahl-Sissoko; Sharla McDonald; William C Weldon; Nicksy Gumede; M Steven Oberste; Olen M Kew; Cara C Burns
Journal:  J Virol       Date:  2018-04-13       Impact factor: 5.103

8.  Identification of two determinants that attenuate vaccine-related type 2 poliovirus.

Authors:  R B Ren; E G Moss; V R Racaniello
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

9.  Multiple viral determinants mediate myopathogenicity in coxsackievirus B1-induced chronic inflammatory myopathy.

Authors:  Patricia E Tam; Melissa L Weber-Sanders; Ronald P Messner
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

10.  Identification of T-helper epitopes in the VP1 capsid protein of poliovirus.

Authors:  M Kutubuddin; J Simons; M Chow
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103
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