Carsten Heinz1, Saskia Schoonbrood2, Arnd Heiligenhaus1. 1. Department of Ophthalmology, St. Franziskus-Hospital Muenster, Muenster, Germany Department of Ophthalmology, University of Duisburg- Essen, Germany. 2. Department of Ophthalmology, St. Franziskus-Hospital Muenster, Muenster, Germany.
Abstract
AIM: Intermediate uveitis (IU) is considered to carry a considerable risk for complications and visual loss. This study compares juvenile and adult onset IU with regard to visual loss and complications. METHODS: Single-centre retrospective analysis of 110 consecutive children with onset of IU at the age of ≤16 years compared with 107 consecutive adult patients (17-35 years). All patients were followed for ≥1 year (mean 2.5±2.3 years). RESULTS: Average age at first uveitis diagnosis in children (65 boys; 59%) was 9.7±3.17 years and in adults was 24.3±4.92 years (36 men; 34%; p=0.003). Best-corrected visual acuity (BCVA) in both groups was similar at first and last presentation. Compared with initial presentation, BCVA improved in 31% of children and 21% of adults during the follow-up period, while it worsened in 9% and 8.7%, respectively. Lyme disease in children (8%) and multiple sclerosis in adults (17%) were the most frequent systemic associations. Poor visual acuity at first presentation, snowbanks and vitreoretinal traction were associated with a higher risk for poor BCVA at last presentation. In children, cataract formation (OR 7.6; 95% CI 1.7 to 33.8) and macular oedema (13.6; 1.6 to 113.5) and in adults posterior synechiae (7.3; 1.8 to 30.2), cataract formation (19.02; 2.31 to 156.56), macular epiretinal membrane (5.1; 1.02 to 25.28) and retinal detachment (8.4; 1.4 to 51.2) were associated with poor BCVA during follow-up. Uveitis course was not worse if associated systemic disease was present. CONCLUSIONS: IU with onset in childhood and early adulthood showed a similar visual course at intermediate follow-up. Associated diseases and complication patterns differed between children and young adults. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
AIM: Intermediate uveitis (IU) is considered to carry a considerable risk for complications and visual loss. This study compares juvenile and adult onset IU with regard to visual loss and complications. METHODS: Single-centre retrospective analysis of 110 consecutive children with onset of IU at the age of ≤16 years compared with 107 consecutive adult patients (17-35 years). All patients were followed for ≥1 year (mean 2.5±2.3 years). RESULTS: Average age at first uveitis diagnosis in children (65 boys; 59%) was 9.7±3.17 years and in adults was 24.3±4.92 years (36 men; 34%; p=0.003). Best-corrected visual acuity (BCVA) in both groups was similar at first and last presentation. Compared with initial presentation, BCVA improved in 31% of children and 21% of adults during the follow-up period, while it worsened in 9% and 8.7%, respectively. Lyme disease in children (8%) and multiple sclerosis in adults (17%) were the most frequent systemic associations. Poor visual acuity at first presentation, snowbanks and vitreoretinal traction were associated with a higher risk for poor BCVA at last presentation. In children, cataract formation (OR 7.6; 95% CI 1.7 to 33.8) and macular oedema (13.6; 1.6 to 113.5) and in adults posterior synechiae (7.3; 1.8 to 30.2), cataract formation (19.02; 2.31 to 156.56), macular epiretinal membrane (5.1; 1.02 to 25.28) and retinal detachment (8.4; 1.4 to 51.2) were associated with poor BCVA during follow-up. Uveitis course was not worse if associated systemic disease was present. CONCLUSIONS: IU with onset in childhood and early adulthood showed a similar visual course at intermediate follow-up. Associated diseases and complication patterns differed between children and young adults. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Entities:
Keywords:
Child health (paediatrics); Immunology; Inflammation
Authors: Osamu Ichikawa; Benjamin S Glicksberg; Nicholas Genes; Brian A Kidd; Li Li; Joel T Dudley Journal: Sci Rep Date: 2019-03-14 Impact factor: 4.379
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