Literature DB >> 24712324

Recent developments on thiourea based anticancer chemotherapeutics.

Vikas Kumar, Swapandeep Singh Chimni1.   

Abstract

The recent emergence of anticancer activity of thiourea derivatives have inspired the medicinal chemist to design and synthesize new thiourea derivatives. These thiourea based anticancer chemotherapeutics inhibit cancer propagation by acting as inhibitors of topoisomerase, protein tyrosine kinase, somatostatin agonists, sirtuins, and carbonic anhydrase (CA). This review summarizes the recent developments on the thiourea based anticancer chemotherapeutics.

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Year:  2015        PMID： 24712324     DOI： 10.2174/1871520614666140407123526

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  6 in total

1.  Enzyme Inhibitory, Antioxidant And Antibacterial Potentials Of Synthetic Symmetrical And Unsymmetrical Thioureas.

Authors:  Sumaira Naz; Muhammad Zahoor; Muhammad Naveed Umar; Barkat Ali; Riaz Ullah; Abdelaaty A Shahat; Hafiz Majid Mahmood; Muhammad Umar Khayam Sahibzada
Journal:  Drug Des Devel Ther       Date:  2019-10-07       Impact factor: 4.162

2.  Synthesis and Antitumor Activities of Chiral Dipeptide Thioureas Containing an Alpha-Aminophosphonate Moiety.

Authors:  Jingzi Liu; Peng Liao; Junfeng Hu; Hong Zhu; Yonglin Wang; Yongjun Li; Yan Li; Bin He
Journal:  Molecules       Date:  2017-02-16       Impact factor: 4.411

3.  Design and synthesis of 4-piperazinyl quinoline derived urea/thioureas for anti-breast cancer activity by a hybrid pharmacophore approach.

Authors:  Raja Solomon Viswas; Sheetal Pundir; Hoyun Lee
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051

4.  N-Naphthoyl Thiourea Derivatives: An Efficient Ultrasonic-Assisted Synthesis, Reaction, and In Vitro Anticancer Evaluations.

Authors:  Wael Abdelgayed Ahmed Arafa; Amira Atef Ghoneim; Asmaa K Mourad
Journal:  ACS Omega       Date:  2022-02-09

5.  Anticancer activity and QSAR study of sulfur-containing thiourea and sulfonamide derivatives.

Authors:  Ratchanok Pingaew; Veda Prachayasittikul; Apilak Worachartcheewan; Anusit Thongnum; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul
Journal:  Heliyon       Date:  2022-08-02

Review 6.  Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis.

Authors:  Riccardo Ronchetti; Giada Moroni; Andrea Carotti; Antimo Gioiello; Emidio Camaioni
Journal:  RSC Med Chem       Date:  2021-05-13
  6 in total

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