Literature DB >> 2471191

A protective monoclonal antibody recognizes a linear epitope in the precursor to the major merozoite antigens of Plasmodium chabaudi adami.

A M Lew1, C J Langford, R F Anders, D J Kemp, A Saul, C Fardoulys, M Geysen, M Sheppard.   

Abstract

The monoclonal antibody 5C10/66 was shown to afford strong protection in mice against fulminating Plasmodium chabaudi adami infection. This was remarkable, as immunity to this organism is regarded to be mainly T-cell mediated. This antibody identified a 250-kDa molecule in schizonts and an 83-kDa fragment in merozoites. A cDNA clone selected by 5C10/66 was the homologue of the Plasmodium falciparum precursor to the major merozoite surface antigen (PMMSA). Comparison with the P. falciparum sequence showed that the P. chabaudi adami clone encoded the middle portion of the gene and that it can also be divided into variable and conserved blocks. Screening of a set of all possible octamer peptides predicted by the cDNA clone revealed that the core epitope of 5C10/66 was Glu-Thr-Thr-Glu-Thr. This region resides in a variable block of PMMSA.

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Year:  1989        PMID： 2471191      PMCID： PMC287221          DOI： 10.1073/pnas.86.10.3768

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

Review 1.  The precursor to major merozoite surface antigens: structure and role in immunity.

Authors:  A A Holder
Journal:  Prog Allergy       Date:  1988

2.  Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.

Authors:  F Sanger; A R Coulson; B G Barrell; A J Smith; B A Roe
Journal:  J Mol Biol       Date:  1980-10-25       Impact factor: 5.469

3.  Immunization against Plasmodium falciparum asexual blood stages using soluble antigens.

Authors:  L H Perrin; M Loche; J P Dedet; C Roussilhon; T Fandeur
Journal:  Clin Exp Immunol       Date:  1984-04       Impact factor: 4.330

4.  Immunization against blood-stage rodent malaria using purified parasite antigens.

Authors:  A A Holder; R R Freeman
Journal:  Nature       Date:  1981-11-26       Impact factor: 49.962

5.  Isolation of malaria merozoites: release of Plasmodium chabaudi merozoites from schizonts bound to immobilized concanavalin A.

Authors:  P H David; M Hommel; J C Benichou; H A Eisen; L H da Silva
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

6.  Monoclonal antibodies against a specific surface determinant on malarial (Plasmodium knowlesi) merozoites block erythrocyte invasion.

Authors:  N Epstein; L H Miller; D C Kaushel; I J Udeinya; J Rener; R J Howard; R Asofsky; M Aikawa; R L Hess
Journal:  J Immunol       Date:  1981-07       Impact factor: 5.422

7.  Passive immunization against murine malaria with an IgG3 monoclonal antibody.

Authors:  W R Majarian; T M Daly; W P Weidanz; C A Long
Journal:  J Immunol       Date:  1984-06       Impact factor: 5.422

8.  Monoclonal antibodies that protect in vivo against Plasmodium chabaudi recognize a 250,000-dalton parasite polypeptide.

Authors:  D B Boyle; C I Newbold; C C Smith; K N Brown
Journal:  Infect Immun       Date:  1982-10       Impact factor: 3.441

9.  Variability in parasite protein antigen structure and protective immunity to malaria.

Authors:  K N Brown; W Jarra; C I Newbold; M Schryer
Journal:  Ann Inst Pasteur Immunol (1985)       Date:  1985 Jan-Feb

10.  Protective Plasmodium knowlesi Mr 74,000 antigen in membranes of schizont-infected rhesus erythrocytes.

Authors:  R Schmidt-Ullrich; J Lightholder; M T Monroe
Journal:  J Exp Med       Date:  1983-07-01       Impact factor: 14.307
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  12 in total

1.  Antibodies that neutralize human beta interferon biologic activity recognize a linear epitope: analysis by synthetic peptide mapping.

Authors:  P N Redlich; P D Hoeprich; C B Colby; S E Grossberg
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

2.  Naturally acquired antibody responses to Plasmodium falciparum merozoite surface protein 4 in a population living in an area of endemicity in Vietnam.

Authors:  L Wang; T L Richie; A Stowers; D H Nhan; R L Coppel
Journal:  Infect Immun       Date:  2001-07       Impact factor: 3.441

3.  Cloning and sequencing of a cDNA fragment from Plasmodium chabaudi chabaudi that contains repetitive sequences coding for a potentially lysine-rich aspartic acid-rich protein.

Authors:  D Hartz; M Ayane; J Chluba-De Tapia; C Wirbelauer; J Langhorne; S Gillard-Blass
Journal:  Parasitol Res       Date:  1993       Impact factor: 2.289

4.  Resolution of acute malarial infections by T cell-dependent non-antibody-mediated mechanisms of immunity.

Authors:  L A Cavacini; L A Parke; W P Weidanz
Journal:  Infect Immun       Date:  1990-09       Impact factor: 3.441

5.  Proteins with molecular masses of 25 to 40 kilodaltons elicit optimal protective responses against Plasmodium chabaudi adami infection.

Authors:  P E Kima; I K Srivastava; C A Long
Journal:  Infect Immun       Date:  1992-12       Impact factor: 3.441

6.  Primary structure of the variable region of monoclonal antibody 2B10, capable of inducing anti-idiotypic antibodies that recognize the C-terminal region of MSA-1 of Plasmodium falciparum.

Authors:  S Su; S Yang; R Ding; E A Davidson
Journal:  Infect Immun       Date:  1996-01       Impact factor: 3.441

7.  A prospective study of the association between the human humoral immune response to Plasmodium falciparum blood stage antigen gp190 and control of malarial infections.

Authors:  R Tolle; K Früh; O Doumbo; O Koita; M N'Diaye; A Fischer; K Dietz; H Bujard
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

8.  A single fragment of a malaria merozoite surface protein remains on the parasite during red cell invasion and is the target of invasion-inhibiting antibodies.

Authors:  M J Blackman; H G Heidrich; S Donachie; J S McBride; A A Holder
Journal:  J Exp Med       Date:  1990-07-01       Impact factor: 14.307

9.  Plasmodium falciparum variability and immune evasion proceed from antigenicity of consensus sequences from DBL6ε; generalization to all DBL from VAR2CSA.

Authors:  Philippe Deloron; Jacqueline Milet; Cyril Badaut
Journal:  PLoS One       Date:  2013-01-25       Impact factor: 3.240

10.  Naturally acquired human antibodies which recognize the first epidermal growth factor-like module in the Plasmodium falciparum merozoite surface protein 1 do not inhibit parasite growth in vitro.

Authors:  J A Chappel; A F Egan; E M Riley; P Druilhe; A A Holder
Journal:  Infect Immun       Date:  1994-10       Impact factor: 3.441
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