| Literature DB >> 24710613 |
Sergio de Almeida Basano1, Gilberto Fontes1, Jansen Fernandes Medeiros1, Juliana Souza de Almeida Aranha Camargo1, Luana Janaína Souza Vera1, Marcos Paulo Parente Araújo1, Maira Santiago Pires Parente1, Ricardo de Godoi Mattos Ferreira1, Pedro di Tárique Barreto Crispim1, Luís Marcelo Aranha Camargo2.
Abstract
Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Lábrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level. © The American Society of Tropical Medicine and Hygiene.Entities:
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Year: 2014 PMID： 24710613 PMCID： PMC4047749 DOI： 10.4269/ajtmh.13-0410
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345