Donald L Chi1, Ohnmar Tut2, Peter Milgrom3. 1. Department of Oral Health Sciences, University of Washington, Seattle, Wash., USA. dchi@uw.edu. 2. Griffith Health Institute, Griffith University, Gold Coast, Australia. 3. Department of Oral Health Sciences, University of Washington, Seattle, Wash., USA.
Abstract
PURPOSE: The purpose of this study was to assess the efficacy of supervised tooth-brushing with xylitol toothpaste to prevent early childhood caries (ECC) and reduce mutans streptococci. METHODS: In this cluster-randomized efficacy trial, 196 four- to five-year-old children in four Head Start classrooms in the Marshall Islands were randomly assigned to supervised toothbrushing with 1,400 ppm/31 percent fluoride xylitol or 1,450 ppm fluoride sorbitol toothpaste. We hypothesized that there would be no difference in efficacy between the two types of toothpaste. The primary outcome was the surface-level primary molar caries increment (d(2-3)mfs) after six months. A single examiner was blinded to classroom assignments. Two classrooms were assigned to the fluoride-xylitol group (85 children), and two classrooms were assigned to the fluoride-sorbitol group (83 children). The child-level analyses accounted for clustering. RESULTS: There was no difference between the two groups in baseline or end-of-trial mean d(2-3)mfs. The mean d(2-3)mfs increment was greater in the fluoride-xylitol group compared to the fluoride-sorbitol group (2.5 and 1.4 d(2-3)mfs, respectively), but the difference was not significant (95% confidence interval: -0.17, 2.37; P=.07). No adverse effects were reported. CONCLUSION: After six months, brushing with a low-strength xylitol/fluoride tooth-paste is no more efficacious in reducing ECC than a fluoride-only toothpaste in a high caries-risk child population.
RCT Entities:
PURPOSE: The purpose of this study was to assess the efficacy of supervised tooth-brushing with xylitol toothpaste to prevent early childhood caries (ECC) and reduce mutans streptococci. METHODS: In this cluster-randomized efficacy trial, 196 four- to five-year-old children in four Head Start classrooms in the Marshall Islands were randomly assigned to supervised toothbrushing with 1,400 ppm/31 percent fluoride xylitol or 1,450 ppm fluoride sorbitol toothpaste. We hypothesized that there would be no difference in efficacy between the two types of toothpaste. The primary outcome was the surface-level primary molar caries increment (d(2-3)mfs) after six months. A single examiner was blinded to classroom assignments. Two classrooms were assigned to the fluoride-xylitol group (85 children), and two classrooms were assigned to the fluoride-sorbitol group (83 children). The child-level analyses accounted for clustering. RESULTS: There was no difference between the two groups in baseline or end-of-trial mean d(2-3)mfs. The mean d(2-3)mfs increment was greater in the fluoride-xylitol group compared to the fluoride-sorbitol group (2.5 and 1.4 d(2-3)mfs, respectively), but the difference was not significant (95% confidence interval: -0.17, 2.37; P=.07). No adverse effects were reported. CONCLUSION: After six months, brushing with a low-strength xylitol/fluoride tooth-paste is no more efficacious in reducing ECC than a fluoride-only toothpaste in a high caries-risk child population.
Authors: K W Stephen; I G Chestnutt; A P Jacobson; D R McCall; R K Chesters; E Huntington; F Schäfer Journal: Int Dent J Date: 1994-06 Impact factor: 2.512
Authors: Donald L Chi; Graciela Zegarra; Elsa C Vasquez Huerta; Jorge L Castillo; Peter Milgrom; Marilyn C Roberts; Ailin R Cabrera-Matta; Ana P Merino Journal: J Dent Child (Chic) Date: 2016-09-15
Authors: Zaira F Kharaeva; Magomet Sh Mustafaev; Anzor V Khazhmetov; Ismail H Gazaev; Larisa Z Blieva; Lukas Steiner; Wolfgang Mayer; Chiara De Luca; Liudmila G Korkina Journal: Dent J (Basel) Date: 2020-01-15